Results 31 to 40 of about 6,006 (50)

Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets

open access: yesActa Pharmaceutica, 2015
During the past few years, the studies of bi- and multi-layered tablets increased due to the consumption of several different drugs per day by a patient and requests for appropriate patient compliance.
Blatnik Sandra Urek   +2 more
doaj   +1 more source

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents

open access: yesActa Pharmaceutica, 2020
The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work.
Çevik Ulviye Acar   +7 more
doaj   +1 more source

High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms

open access: yesActa Pharmaceutica, 2016
A novel, simple and robust high-performance liquid chromatography (HPLC) method was developed and validated for simultaneous determination of xipamide (XIP), triamterene (TRI) and hydrochlorothiazide (HCT) in their bulk powders and dosage forms ...
Abd El-Hay Soad S.   +2 more
doaj   +1 more source

Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

open access: yesActa Pharmaceutica, 2020
A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT).
Vlachou Marilena   +7 more
doaj   +1 more source

Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability

open access: yesActa Pharmaceutica, 2019
The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach.
Rutckeviski Renata   +7 more
doaj   +1 more source

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

open access: yesActa Pharmaceutica, 2019
Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC ...
Sabran Affidah   +2 more
doaj   +1 more source

Identification of new process-related impurity in the key intermediate in the synthesis of TCV-116

open access: yesActa Pharmaceutica, 2019
Development of safe and effective drugs requires complete impurity evaluation and, therefore, knowledge about the formation and elimination of impurities is necessary.
Testen Ana   +3 more
doaj   +1 more source

Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet formulations

open access: yesActa Pharmaceutica, 2019
The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and diluent factors at three levels
Barbosa Eduardo José   +1 more
doaj   +1 more source

Actualities in the phytochemical research on selected terpenes

open access: yesActa Pharmaceutica, 2019
A short review of our recent research on the essential oil phytochemical composition of Petasites albus (L.) Gaertn. and Petasites hybridus (L.) G. Gaertn., B. Mey. & Scherb.
Jerković Igor   +2 more
doaj   +1 more source

Screening of flavonoid aglycons’ metabolism mediated by the human liver cytochromes P450

open access: yesActa Pharmaceutica, 2019
Biological effects of flavonoids have been extensively studied in the last 80 years. As flavonoids represent a rather large group of compounds, data on metabolic biotransformations of these compounds is relatively limited to those well studied.
Benković Goran   +3 more
doaj   +1 more source

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