Results 41 to 50 of about 6,294 (108)

SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1

Acta Pharmaceutica, 2020
The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells.
Zheng Bin, Wang Gang, Gao Wenbo, Wu Qiquan, Zhu Weizhi, Weng Guobin   +5 more
doaj   +1 more source

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films

Acta Pharmaceutica, 2020
Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method
Grilc Blaž, Zdovc Jurij, Planinšek Odon   +2 more
doaj   +1 more source

Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets

Acta Pharmaceutica, 2015
During the past few years, the studies of bi- and multi-layered tablets increased due to the consumption of several different drugs per day by a patient and requests for appropriate patient compliance.
Blatnik Sandra Urek, Dreu Rok, Srčič Stanko   +2 more
doaj   +1 more source

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents

Acta Pharmaceutica, 2020
The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work.
Çevik Ulviye Acar, Osmaniye Derya, Levent Serkan, Sağlik Begüm Nurpelin, Çavuşoğlu Betül Kaya, Karaduman Abdullah Burak, Özkay Yusuf, Kaplancikli Zafer Asim   +7 more
doaj   +1 more source

High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms

Acta Pharmaceutica, 2016
A novel, simple and robust high-performance liquid chromatography (HPLC) method was developed and validated for simultaneous determination of xipamide (XIP), triamterene (TRI) and hydrochlorothiazide (HCT) in their bulk powders and dosage forms ...
Abd El-Hay Soad S., Hashem Hisham, Gouda Ayman A.   +2 more
doaj   +1 more source

Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

Acta Pharmaceutica, 2020
A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT).
Vlachou Marilena, Siamidi Angeliki, Goula Efstratia, Georgas Panagiotis, Pippa Natassa, Karalis Vangelis, Sentoukas Theodore, Pispas Stergios   +7 more
doaj   +1 more source

Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability

Acta Pharmaceutica, 2019
The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach.
Rutckeviski Renata, Xavier Francisco Humberto, Morais Andreza Rochelle Do Vale, Amaral-Machado Lucas, Alencar Everton Do Nascimento, Genre Julieta, De Souza Araujo Adriano Antunes, Egito Eryvaldo Socrates Tabosa Do   +7 more
doaj   +1 more source

Highly conserved regions in Ebola virus RNA dependent RNA polymerase may be act as a universal novel peptide vaccine target: a computational approach

In Silico Pharmacology, 2015
Ebola virus (EBOV) is such kind of virus which is responsible for 23,825 cases and 9675 deaths worldwide only in 2014 and with an average diseases fatality rate between 25 % and 90 %.
A. R. Oany, Tahmina Sharmin, Afrin Sultana Chowdhury, Tahmina Pervin Jyoti, Md. Anayet Hasan   +4 more
semanticscholar   +1 more source

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

Acta Pharmaceutica, 2019
Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononu-clear cells (PBMC ...
Sabran Affidah, Kumolosasi Endang, Jantan Ibrahim   +2 more
doaj   +1 more source

Identification of new process-related impurity in the key intermediate in the synthesis of TCV-116

Acta Pharmaceutica, 2019
Development of safe and effective drugs requires complete impurity evaluation and, therefore, knowledge about the formation and elimination of impurities is necessary.
Testen Ana, Plevnik Miha, Štefane Bogdan, Cigić Irena Kralj   +3 more
doaj   +1 more source