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Current Advances in Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, and Future Perspectives

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells.
Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh   +5 more
doaj   +1 more source

Can Coffee Combat Fatty Liver? A Review of Emerging Evidence

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
NAFLD (Non-alcoholic fatty liver disease) is an increasingly spread metabolic status characterized by increasing fat accumulation in the liver, obesity closely associated with it, sedentary habits and insulin resistance.
Mohamed E. Abd El-Hack, Muhammad Arif, Vincenzo Tufarelli, Ayman A. Swelum   +3 more
doaj   +1 more source

Quality of Life Among Type II Diabetes Mellitus Patients

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Type 2 diabetes mellitus (T2DM) is a significant public health concern Approximately 90% of people with diabetes worldwide have diabetes mellitus type 2.
Duaa Dhia Hameed Al-Baghdadi, Rajha Abdul Hassan Hamza   +1 more
doaj   +1 more source

Computational Design, Molecular Docking, SAR, and ADMET Analysis of Novel JAK1 Inhibitors as a Possible Treatment for Rheumatoid Arthritis

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Rheumatoid arthritis is an inflammatory autoimmune disease affecting the joints which eventually leads to systemic comorbidities. Its pathogenesis was attributed to disturbances in the Janus Kinase/Signal Transducer and Activator of Transcription ...
Sarah Ahmed Waheed
doaj   +1 more source

Preparation and In Vitro Evaluation of Gastro-retentive Tablets of Frusemide Using Gas Generating Excipients as Floating Mechanism

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.Floating tablets are one of the dosage forms ...
Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed   +2 more
doaj   +1 more source

Structure-Based Repurposing of Clinically Approved Compounds for PDE-5 Inhibition: Integrative Computational and Pharmacokinetic Evaluation

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Phosphodiesterase-5 (PDE-5) regulates intracellular cyclic guanosine monophosphate (cGMP) levels, modulating vascular smooth muscle tone.
Albashir Tahir, Yasir Idris Saleh, Ibrahim Khaleel Muazu   +2 more
doaj   +1 more source

Design and Mechanistic Investigation of Novel Metallodrugs: From Structure-Activity Relationships to Selective Cancer Cell Targeting

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
The relentless pursuit of alternatives to conventional platinum-based chemotherapeutics, hampered by severe side effects and drug resistance, defines a critical frontier in oncology drug discovery. This review consolidates and highlights the significance
Samad Khaksar, Nosrat Behzadi, Hasan Zakeri Zakeri, Peyman Salahshour, Sara Abdolmaleki   +4 more
doaj   +1 more source

Recent Updates on Orally Disintegrating Films Regarding Design, Characterization, and Assessment

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Orally disintegrating films (ODFs) are a pharmaceutical dosage form that liquefies or disintegrates rapidly in the mouth without water, creating an attractive option for patients with difficulty swallowing.
Asmaa Abdelaziz Mohamed, Firas Aziz Rahi   +1 more
doaj   +1 more source

Impact of Erythropoietin Therapy on Inflammatory Biomarkers in Chronic Kidney Disease: A Comparative Study

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Chronic kidney disease (CKD) is a progressive disorder frequently complicated by anemia and a persistent inflammatory state, both of which significantly contribute to morbidity and mortality.
Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi   +2 more
doaj   +1 more source

Emerging advancements and expanding technological scope of education and practices in pharmacy and pharmaceutical sciences. [PDF]

Bioimpacts
Barar J, Fiano K, Seamon M, Albensi B, Khanfar N, Omidi Y.   +5 more
europepmc   +1 more source