Results 41 to 50 of about 173,990 (255)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Classification of Brain Tumor Using Hybrid Pre-Trained Networks and MRMR Algorithm

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Brain tumor classification is one of the crucial uses of medical image processing. A longer life is possible if the tumor is correctly and promptly diagnosed.
Mustafa Ridha Al-Yasari, Mohammed Qasim Alazzawi, Sarmad Jawad, Mohammed Alshujairi, Zamzam Ali Abood Noory Al-Shafiee, Jaber Parchami, Heba. G. Abdelzaher, M. A. Abdelzaher   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Evaluation of RBC Indices and Significance of Mentzer Index for Differentiation Between Iron Deficiency Anemia and Beta Thalassemia Trait

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Anemia is a global public health problem affecting developed and adversely affecting developing countries. About 1.62 billion peoples are affected worldwide, currently pregnant women are the most vulnerable population corresponding to 24.8 ...
Raghda Hameed Jasim, Rasha Hussain Aouda   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Instruction Program for Patients with Cholecystectomy Regarding Nutritional Knowledge

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
The primary objective of this study is to assess the level of patients' understanding of the educational program following cholecystectomy. Additionally, the study attempts to determine the correlation between patients' knowledge and their socio ...
Haider Naiser Mousa, Huda Baqir Hassan
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Greenness Assessment and Development of an Innovative HPLC Method for the Determination of Rifaximin and Sodium Benzoate in Oral Suspension

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
The pharmaceutical industry has brought advancement and opportunities. However, it has also presented challenges and complexity that must be addressed.
Hani M. Hafez, Naser F. Al-Tannak, Mohamed A. Rabeh   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Assessing Pharmacy Students' Knowledge and Awareness Regarding the Rational Utilization of Antibiotics and the Issue of Antimicrobial Resistance in Iraq

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Introduction: The Non rational use and overall volume of antibiotic consumption in the community is one of the foremost causes of antimicrobial resistance.
Hasanain Kamil Hasan, Mohamed Mahmoud AbdElrahman, Ali A. R. Aldallal, Hayder Ridha Salman, Montadher Mohammad Majeed, Mohammad Jabbar Hassan, Alaa Shukry Mtasher, Ahmed Majid Ibrahim   +7 more
doaj   +1 more source