Results 61 to 70 of about 195,932 (292)

Pharmaceutical Scientists' Perspectives on Capacity Building in Pharmaceutical Sciences [PDF]

, 2023
With the anticipated health challenges brought by demographic and technological changes, ensuring capacity in underlying workforce in place is essential for addressing patients' needs.
Kusynová, Z, van den Ham, H A, Mantel-Teeuwisse, A K, Leufkens, H G M   +3 more
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Synthesis and Characterization of Novel Derivatives of Imides 1,2,4-triazole Polymers via Microwave and Study Biological Activities

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
New derivatives of imides 1,2,4-triazole polymers as pharmaceutical compounds were prepared from the synthesis of amic acid compounds (1A-E) by reacted of benzocaine with different cyclic anhydrides.
Bahaa Fadhil Hamzah
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Risk Factors Which Effect the Maturity of Placenta

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Back ground Proper placental development is essential for a successful pregnancy. An important organ, the placenta carries out several physiological, immunological, and endocrine functions. It also performs vital roles in mediating the exchange of gasses,
Eftkar Hamza Skair, Saadya Hadi Humade, Rania Abd Elmohsen Abo El nour, Maryam Amer Ajam   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Preparation and Characterization Using a New Schiff Base Ligand Derived from Benzoyl Isothiocyanate with Their Complexes and Study of Their Biological Activity

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Complexes containing Nickel, Copper, and Zinc salts were prepared and studied in this study. Additionally, novel Schiff Base ligands were synthesized by reacting 6-aminopenicillinic acid with benzoyl isothiocyanate to produce L.
Zaynab Faleh AI-Janahi, Mohammed Hamid Said   +1 more
doaj   +1 more source

Conference 2014: Promoting Today's Ideas for Tomorrow's Medicine: Pharmaceutical Science to Regulatory Science. An international symposium held jointly by CSPS and CC-CRS, June 10-13, 2014, Montreal, QC, Canada

, 2014
Plenaries and Special Presentations:Supriya Sharma, Acting Associate Assistant Deputy Minister, Health Canada:  "Facing Tomorrow's Regulatory Challenges Today"Mick Bhatia, McMaster Stem Cell and Cancer Research Institute (SCC-RI): "Potential Applications
Canadian Society for Pharmaceutical Sciences (CSPS), (CSPS), Canadian Society for Pharmaceutical Sciences   +1 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

DICLOFENAC: A Review on Its Synthesis, Mechanism of Action, Pharmacokinetics, Prospect and Environmental Impact

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Diclofenac, potent a nonsteroidal anti-inflammatory drug, used in the treatment of inflammation, pain and fever associated with a wide range of disease condition.
Hind A. Satar, Emad Yousif, Ahmed Ahmed   +2 more
doaj   +1 more source