Results 61 to 70 of about 173,990 (255)

The role of science, practice and education in building capacity for pharmacy and pharmaceutical sciences

, 2023
Capacity building involves development of human and institutional resources by enhancing individual skills and strengthening organisational competence to perform specific tasks more effectively. The topic of capacity building in healthcare is gaining more dominance in policy discourses on international development, mostly driven by the United Nation’s ...
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

In Silico Evaluation of Nigella sativa Phytocompounds as Potential Modulators of Estrogen Receptor Alpha: A Molecular Docking and ADMET Study

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Reproductive dysfunction among women remains a pressing global health issue, often linked to hormonal imbalances involving estrogen receptor alpha (ERα).
Murtala Muhammad Jibril, Samuel Otokpa Ede, Ekwere O. Ekwere   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

GC-MS Analysis of Bioactive Constituents From the Leaves of Portulaca afra Jacq. and Portulaca grandiflora Hook

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Portulaca afra and Portulaca grandiflora are traditional medicinal that grow as ornamental plants in Iraq. The present study was conducted for GC-MS analysis of the leaves of these plants to identify possible bioactive compounds.
Sadeq S.K.AL-Taie, Noor F.M. AL-Kenane, Zaidon T. Al-aqbi   +2 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Evaluation of the Compliance of Ultra-Low Dose Drugs Available in Local Iraqi Markets with Regulatory Weight Variation Test

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Mixing and formulation of drugs with very low dose is a brutal challenge to formulators sometimes due to all kinds of difficulties like segregation, content uniformity and physicochemical stability issues.
Yousif K. Younis
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

journal
openaire   +3 more sources

Buccal Films as an Emerging Drug Delivery System: A Comprehensive Review

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Oral administration through the digestive tract is still the most common means by which drugs are given, as it is simple and cheap. However, it has some biopharmaceutical limitations in general, such as varying gastrointestinal conditions, enzymatic ...
Syed Faizan Syed Nizamuddin, Nishan N. Bobade, Vikrant P. Wankhade, Sandeep C. Atram, Shrikant D. Pande, Nakul S. Dhore, Shraddha P. Malpani, Ashwin A. Pahurkar   +7 more
doaj   +1 more source