Results 81 to 90 of about 173,990 (255)

Structure-Based Repurposing of Clinically Approved Compounds for PDE-5 Inhibition: Integrative Computational and Pharmacokinetic Evaluation

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Phosphodiesterase-5 (PDE-5) regulates intracellular cyclic guanosine monophosphate (cGMP) levels, modulating vascular smooth muscle tone.
Albashir Tahir, Yasir Idris Saleh, Ibrahim Khaleel Muazu   +2 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Design and Mechanistic Investigation of Novel Metallodrugs: From Structure-Activity Relationships to Selective Cancer Cell Targeting

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
The relentless pursuit of alternatives to conventional platinum-based chemotherapeutics, hampered by severe side effects and drug resistance, defines a critical frontier in oncology drug discovery. This review consolidates and highlights the significance
Samad Khaksar, Nosrat Behzadi, Hasan Zakeri Zakeri, Peyman Salahshour, Sara Abdolmaleki   +4 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Recent Updates on Orally Disintegrating Films Regarding Design, Characterization, and Assessment

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Orally disintegrating films (ODFs) are a pharmaceutical dosage form that liquefies or disintegrates rapidly in the mouth without water, creating an attractive option for patients with difficulty swallowing.
Asmaa Abdelaziz Mohamed, Firas Aziz Rahi   +1 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Can Coffee Combat Fatty Liver? A Review of Emerging Evidence

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
NAFLD (Non-alcoholic fatty liver disease) is an increasingly spread metabolic status characterized by increasing fat accumulation in the liver, obesity closely associated with it, sedentary habits and insulin resistance.
Mohamed E. Abd El-Hack, Muhammad Arif, Vincenzo Tufarelli, Ayman A. Swelum   +3 more
doaj   +1 more source

Physical Pharmacy: Physical Chemical Principles in Pharmaceutical Science

American Journal of Pharmaceutical Education, 1958
Includes bibliography. ; Mode of access: Internet.
openaire   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Quality of Life Among Type II Diabetes Mellitus Patients

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Type 2 diabetes mellitus (T2DM) is a significant public health concern Approximately 90% of people with diabetes worldwide have diabetes mellitus type 2.
Duaa Dhia Hameed Al-Baghdadi, Rajha Abdul Hassan Hamza   +1 more
doaj   +1 more source