Results 31 to 40 of about 9,799 (116)

Dendrimer functionalized folate-targeted gold nanoparticles for luciferase gene silencing in vitro: A proof of principle study

open access: yesActa Pharmaceutica, 2019
Use of exogenous small interfering RNA (siRNA) has shown potential in gene silencing. The need for target-specific siRNA delivery vehicles is crucial to successful gene silencing. This study is aimed at developing and evaluating the safety and efficiency
Mbatha Londiwe Simphiwe   +2 more
doaj   +1 more source

Advancements in electron paramagnetic resonance (EPR) spectroscopy: A comprehensive tool for pharmaceutical research

open access: yesActa Pharmaceutica
Electron paramagnetic resonance (EPR) spectroscopy has long been established across various scientific disciplines for characterizing organic radicals, organometallic complexes, protein structures and dynamics, polymerization processes, and radical ...
Bešić Erim   +2 more
doaj   +1 more source

Evaluation of phenylethylamine type entactogens and their metabolites relevant to ecotoxicology – a QSAR study

open access: yesActa Pharmaceutica, 2019
The impact of the selected entactogens and their o-quinone metabolites on the environment was explored in QSAR studies by the use of predicted molecular descriptors, ADMET properties and environmental toxicity parameters, i.e., acute toxicity in ...
Takač Milena Jadrijević-Mladar   +2 more
doaj   +1 more source

SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1

open access: yesActa Pharmaceutica, 2020
The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells.
Zheng Bin   +5 more
doaj   +1 more source

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films

open access: yesActa Pharmaceutica, 2020
Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method
Grilc Blaž   +2 more
doaj   +1 more source

Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets

open access: yesActa Pharmaceutica, 2015
During the past few years, the studies of bi- and multi-layered tablets increased due to the consumption of several different drugs per day by a patient and requests for appropriate patient compliance.
Blatnik Sandra Urek   +2 more
doaj   +1 more source

Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents

open access: yesActa Pharmaceutica, 2020
The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work.
Çevik Ulviye Acar   +7 more
doaj   +1 more source

High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms

open access: yesActa Pharmaceutica, 2016
A novel, simple and robust high-performance liquid chromatography (HPLC) method was developed and validated for simultaneous determination of xipamide (XIP), triamterene (TRI) and hydrochlorothiazide (HCT) in their bulk powders and dosage forms ...
Abd El-Hay Soad S.   +2 more
doaj   +1 more source

Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

open access: yesActa Pharmaceutica, 2020
A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT).
Vlachou Marilena   +7 more
doaj   +1 more source

Genetic Manipulation of Murine Retinal Stem Cells

open access: yes, 2007
http://hdl.handle.net/20.500.11768 ...
Giannelli SG   +4 more
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