Results 41 to 50 of about 6,006 (50)

Solving manufacturing problems for L-carnitine-L-tartrate to improve the likelihood of successful product scale-up

open access: yesActa Pharmaceutica, 2017
L-carnitine-L-tartrate, a non-essential amino acid, is hygroscopic. This causes a problem in tablet production due to pronounced adhesion of tablets to punches. A 33 full factorial design was adopted to suggest a tablet formulation. Three adsorbents were
Badawi Aliaa A.   +3 more
doaj   +1 more source

Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents

open access: yesActa Pharmaceutica, 2014
A novel series of thiophenes having biologically active sulfonamide 2-11, 3-methylisoxazole 12, 4-methoxybenzo[d] thiazole 13, quinoline 14, 15, benzoylphenylamino 16, and anthracene-9,10-dione 17 moieties were prepared.
Ghorab Mostafa M.   +2 more
doaj   +1 more source

Effective anti-adhesives of uropathogenic Escherichia coli

open access: yesActa Pharmaceutica, 2018
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance ...
Ribić Rosana   +3 more
doaj   +1 more source

Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol

open access: yesActa Pharmaceutica, 2018
The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution, in ...
Shehzadi Naureen   +8 more
doaj   +1 more source

Acalypha Wilkesiana ‘Java White’: Identification of Some Bioactive Compounds by Gc-Ms and Their Effects on Key Enzymes Linked to Type 2 Diabete

open access: yesActa Pharmaceutica, 2018
In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 ...
Oyebode Olajumoke A.   +3 more
doaj   +1 more source

Immunomodulatory Effects of Tigecycline in Balb/C Mice

open access: yesActa Pharmaceutica, 2018
Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for
Elhayek Shada Y.   +4 more
doaj   +1 more source

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways

open access: yesActa Pharmaceutica, 2019
The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2.
Liu Rui   +5 more
doaj   +1 more source

Nutrition – facts and myths

open access: yesActa Pharmaceutica, 2019
Taking responsibility for your life, among other factors, means also considering what to eat and which nutrition pattern to follow. Everyone needs to think about what they put on the plate and which ingredients should be avoided.
Verbanac Donatella   +2 more
doaj   +1 more source

Druggability and molecular docking of essential secondary metabolites from Azadirachta indica leaf against angiotensin converting enzyme-2: Covid-19 in focus

open access: yesAfrican Journal of Pharmaceutical Research and Development (AJOPRED)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious and virulent coronavirus that arose in late 2019 and poses great risk to public health and safety.
Paul Chijioke Ozioko   +2 more
doaj  

Effect of extract and fractions of stem bark of Morinda lucida Benth (Rubicaceae) on castor-oil induced diarrhea in mice

open access: yesAfrican Journal of Pharmaceutical Research and Development (AJOPRED)
Morinda lucida Benth is a common Nigerian medicinal plant generally used to cure malaria parasite infection, though there is a lack of scientific reports on its capacity to treat diarrhea.
Ibeabuchi Jude Ali   +9 more
doaj  

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