Results 171 to 180 of about 110,208 (302)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Role of histone deacetylases and sirtuins in the ischaemic stroke: a systematic review and meta-analysis of animal studies. [PDF]

Stroke Vasc Neurol
Majdi A, Yaraghi S, Moharrami A, Ghaffari Tabrizi A, Dojahani M, Alirezapour E, Mansori K, Eskandari M, Mostafavi H.   +8 more
europepmc   +1 more source

Curcumin in High Doses Reverses the UV-B-Induced <i>DNMT</i> and <i>HDAC</i> Upregulation In Vitro: A Novel Anti-Cancer Approach? [PDF]

Pharmaceuticals (Basel)
Zand A, Raposa BL, Szép D, Macharia JM, Nowrasteh G, Budán F, Varjas T.   +6 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

HDACs targeting from traditional Chinese medicine: mechanisms and therapeutic potential in rheumatoid arthritis. [PDF]

Front Pharmacol
Sun C, Lv S.
europepmc   +1 more source

Diaphragm‐specific effects of L‐citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L‐citrulline, a precursor of L‐arginine, required for NO production in muscle, which is reduced in dystrophic mdx muscle ...
Lisamaura Tulimiero, Brigida Boccanegra, Paola Mantuano, Antonietta Mele, Michela De Bellis, Roberta Lenti, Francesca Sanarica, Santa Cirmi, Elena Conte, Ornella Cappellari, Amber E. Sherrard, Ardawna Green, Mira Srinivasa, Marta L. Fiorotto, Annamaria De Luca   +14 more
wiley   +1 more source

Histone deacetylases: Function in tumor development and therapeutic prospects (Review). [PDF]

Oncol Lett
Lin R, Zhang Y, Li H, Liang F.
europepmc   +1 more source

Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL‐Fusion Leukemia

Cancer Science, EarlyView.
Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Anpei Li, Yuan Zhang, Ziwei Li, Anhao Liu, Li Zhang, Shubin Gao, Xiao Lin, Xiaoming Liu, Huan Li, Guanghui Jin, Bin Xu   +10 more
wiley   +1 more source

HosA-mediated epigenetic regulation of growth, virulence, and secondary metabolism in <i>Aspergillus fumigatus</i>. [PDF]

Virulence
Zhou Z, Zhu Y, Gao R, Wang Y, Chen Y, Lu L, Zhang Y.   +6 more
europepmc   +1 more source

Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function [PDF]

, 2019
Glauben, Rainer, Siegmund, Britta, Weidinger, Carl, Yerinde, Cansu   +3 more
core   +1 more source