Results 261 to 270 of about 110,208 (302)
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HDACs and HDAC Inhibitors in Urothelial Carcinoma – Perspectives for an Antineoplastic Treatment
Current Medicinal Chemistry, 2017Histone deacetylases (HDACs) influence diverse cellular processes and may contribute to tumor development and progression by multiple mechanisms. Class I HDACs are often overexpressed in cancers contributing to a genome-wide epigenetic state permitting increased proliferation, and diminished apoptosis and cell differentiation.
Maria, Pinkerneil +3 more
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ChemInform Abstract: Inside HDAC with HDAC Inhibitors
ChemInform, 2010AbstractReview: 90 refs.
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Choosing pan-HDAC or selective HDAC inhibitors for anticancer therapy
Drug Discovery TodayDysfunction of histone deacetylases (HDACs) is linked to oncogenesis and progression. The expression of classical HDACs varies across different cancers. In some cancers, isozymes of one HDAC class are overactive, whereas in others, multiple classes are involved.
Shabir Ahmad Ganai +2 more
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Teratogenic Activity of HDAC Inhibitors
Current Pharmaceutical Design, 2014Modification of the terminal tails of histones is considered one of the documented mechanisms for epigenetic control of gene expression. Histone deacetylase inhibitors (HDACi) lead to a state of hyperacetylation of histone, a condition that can affect normal gene transcription.
E. Giavini, E. Menegola
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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
Nature Biotechnology, 2011The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and anti-inflammatory properties remains challenging in large part owing to the difficulty of probing the interaction of small molecules with megadalton protein complexes. A combination of affinity capture and quantitative mass spectrometry revealed the selectivity with
Marcus, Bantscheff +23 more
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2007
DNA in eukaryotes is arranged into higher order structures termed chromatin. Chromatin poses an obstacle for gene transcription because it is not readily accessible to DNA binding transcription factors. Chromatin also provides the structural basis for gene regulation, keeping most genes in a default state of repression.
Timothy A. Bolger +2 more
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DNA in eukaryotes is arranged into higher order structures termed chromatin. Chromatin poses an obstacle for gene transcription because it is not readily accessible to DNA binding transcription factors. Chromatin also provides the structural basis for gene regulation, keeping most genes in a default state of repression.
Timothy A. Bolger +2 more
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Functional Analysis of HDACs in Tumorigenesis
2019HDACs, originally described as histone modifiers, have recently been demonstrated to modify a variety of other proteins that are involved in diverse cellular processes unrelated to the chromatin environment. This includes deacetylation of nonhistone targets involved in multiple signaling pathways.
Melissa, Hadley +3 more
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HDAC Inhibitors and Cancer Therapy
2010Maintenance of normal cell growth and differentiation is highly dependent on coordinated and tight transcriptional regulation of genes. In cancer, genes encoding growth regulators are abnormally expressed. Particularly, silencing of tumor suppressor genes under the control of chromatin modifications is a major underlying cause of unregulated cellular ...
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Anticancer properties of chimeric HDAC and kinase inhibitors
Seminars in Cancer Biology, 2022Bernhard Biersack, Michael Höpfner
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Recent developments of HDAC inhibitors: Emerging indications and novel molecules
British Journal of Clinical Pharmacology, 2021Misty M Attwood +2 more
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