Results 1 to 10 of about 3,384,133 (256)
Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma
International Journal of Cancer, 2020 Pancreatic ductal adenocarcinoma (PDAC) is resistant to virtually all chemo‐ and targeted therapeutic approaches. Epigenetic regulators represent a novel class of drug targets.
Feda H Hamdan +2 more
exaly +2 more sources
Cancer Cell, 2019 H3K27M mutations resulting in epigenetic dysfunction are frequently observed in diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer.
Barry M Zee +2 more
exaly +2 more sources
HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation
Cell Chemical Biology, 2017 Summary Histone deacetylase 1 (HDAC1) is an epigenetic enzyme that regulates key cellular processes, such as cell proliferation, apoptosis, and cell survival, by deacetylating histone substrates.
Dhanusha A Nalawansha, Mary Kay H Pflum
exaly +2 more sources
EMBO Molecular Medicine, 2015 Therapy resistance is a major clinical problem in cancer medicine and crucial for disease relapse and progression. Therefore, the clinical need to overcome it, particularly for aggressive tumors such as pancreatic cancer, is very high.
Simone Brabletz +2 more
exaly +2 more sources
Development of a Chimeric c-Src Kinase and HDAC Inhibitor
ACS Medicinal Chemistry Letters, 2013 On the basis of synergism observed between a selective c-Src kinase inhibitor with an HDAC inhibitor, the development of the first chimeric c-Src kinase and HDAC inhibitor is described.
Michael E Steffey, Matthew B Soellner
exaly +2 more sources
Synthesis of a HDAC inhibitor-nanogold probe for cryo-EM visualization in class I HDAC co-repressor complexes. [PDF]
Beilstein J Org ChemClass I histone deacetylases (HDACs 1–3) serve as catalytic subunits within seven multiprotein co-repressor complexes, each of which has distinct functions in the cell.
Pytel WA, Schwabe JWR, Hodgkinson JT.
europepmc +2 more sources
The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
Communications Biology, 2023 Protein acetylation plays a key role in regulating cellular processes and is subject to aberrant control in diverse pathologies. Although histone deacetylase (HDAC) inhibitors are approved drugs for certain cancers, it is not known whether they can be ...
Geng-Hung Liu +9 more
semanticscholar +1 more source
Cancer Research, 2021 The dual PI3K/HDAC inhibitor BEBT-908 elicits potent anti-tumor responses, effectively inducing immunogenic ferroptosis of tumor cells and potentiating cancer immunotherapy.
F. Fan +11 more
semanticscholar +1 more source
Therapeutic potential of tucidinostat, a subtype-selective HDAC inhibitor, in cancer treatment
Frontiers in Pharmacology, 2022 Histone deacetylase (HDAC) is one of the most characterized epigenetic modifiers, modulating chromatin structure and gene expression, which plays an important role in cell cycle, differentiation and apoptosis.
Yichen Sun +6 more
semanticscholar +1 more source
4-Hexylresorcinol Inhibits Class I Histone Deacetylases in Human Umbilical Cord Endothelial Cells
Applied Sciences, 2021 Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance.
Jwa-Young Kim +4 more
doaj +1 more source