Results 31 to 40 of about 3,384,133 (256)
Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models. [PDF]
PLoS ONE, 2012 BACKGROUND: Compound targeting histone deacetylase (HDAC) represents a new era in molecular cancer therapeutics. However, effective HDAC inhibitors for the treatment of solid tumors remain to be developed. METHODOLOGY/PRINCIPAL FINDINGS: Here, we propose
Jiunn-Min Shieh +11 more
doaj +1 more source
Effects of the histone deacetylase inhibitor valproic acid on human pericytes in vitro. [PDF]
PLoS ONE, 2011 Microvascular pericytes are of key importance in neoformation of blood vessels, in stabilization of newly formed vessels as well as maintenance of angiostasis in resting tissues.
Jakob Karén +5 more
doaj +1 more source
Frontiers in Immunology, 2018 Histone deacetylases (HDAC) are one of the key epigenetic modifiers that control chromatin accessibility and gene expression. Their role in tumorigenesis is well established and HDAC inhibitors have emerged as an effective treatment modality.
Sajad A. Bhat +5 more
doaj +1 more source
Nanomaterials as potential transporters of HDAC inhibitors
Medicine in Drug Discovery, 2020 Nanomedicine that combines technology with medical diagnostics and therapeutics is now advancing to greater heights for its significant potential in drug delivery.
Cristabelle De Souza +3 more
doaj +1 more source
Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Persistent infection by the high-risk human papillomaviruses (HPVs) can lead to anogenital and head and neck cancers. The HPV vaccines effectively prevent new type-restricted infections but have no effect on preexisting infections.
N. Banerjee +3 more
semanticscholar +1 more source
Scientific Reports, 2017 Pancreatic cancer is predominantly lethal, and is primarily treated using gemcitabine, with increasing resistance. Therefore, novel agents that increase tumor sensitivity to gemcitabine are needed.
H. Lee +8 more
semanticscholar +1 more source
Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition
Molecules, 2018 We designed and synthesized carbamates of the clinically-approved HDAC (histone deacetylase) inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) in order to validate our previously-proposed hypothesis that these carbamates might serve as ...
Kristina King +4 more
doaj +1 more source
Translational Oncology, 2021 Cancer cell phenotypes evolve during a tumor's treatment. In some cases, tumor cells acquire cancer stem cell-like (CSL) traits such as resistance to chemotherapy and diminished differentiation; therefore, targeting these cells may be therapeutically ...
Feng Chi +10 more
doaj +1 more source
HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases
Chonnam medical journal, 2016 Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated
Somy Yoon, G. Eom
semanticscholar +1 more source
Cell Death and Disease, 2018 Spinal cord injury (SCI) induces severe and long-lasting neurological disability. Accumulating evidence has suggested that histone deacetylase (HDAC) inhibitors exert neuroprotective effects against various insults and deficits in the central nervous ...
Suxiang Zhang +3 more
semanticscholar +1 more source