Results 1 to 10 of about 110,208 (302)
Synthesis of a HDAC inhibitor–nanogold probe for cryo-EM visualization in class I HDAC co-repressor complexes [PDF]
Beilstein Journal of Organic ChemistryClass I histone deacetylases (HDACs 1–3) serve as catalytic subunits within seven multiprotein co-repressor complexes, each of which has distinct functions in the cell.
Wiktoria A. Pytel +2 more
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Differential effects of HDAC inhibitors in the Rho I255d mouse model for autosomal dominant retinitis pigmentosa [PDF]
Cell Death DiscoveryRetinitis Pigmentosa (RP) is an inherited neurodegenerative disease which leads to loss of retinal photoreceptors and blindness. Histone deacetylases (HDAC) were previously found to be involved in photoreceptor cell death, and HDAC inhibitors have shown ...
Yu Zhu +3 more
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The Effect of Quisinostat as the HDAC Inhibitor on Migration [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2021 Background and Aim: Cancer cannot be explained only by genetic alterations but involves epigenetic processes. Modifying histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between Histone ...
Marjan Hajimoradi Javarsiani +2 more
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EFFECT OF SAHA AND C-JUN N-TERMINAL KINASE INHIBITOR ON THE INDUCIBLE MRNA EXPRESSION OF INTERLEUKIN-17 [PDF]
Journal of IMAB, 2023 Interleukin-17 (IL-17A) is a critical cytokine for immune defence against extracellular bacterial and fungal infections. Excess production during chronic inflammation has been associated with many inflammatory and autoimmune disorders. On the other hand,
Boncho Grigorov +4 more
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Next-Generation HDAC Inhibitors: Advancing Zinc-Binding Group Design for Enhanced Cancer Therapy [PDF]
CellsHistone deacetylases (HDACs) are pivotal epigenetic regulators that control gene expression, cell proliferation, and differentiation, and their dysregulation is closely associated with the onset and progression of multiple cancers.
Mohammed Hawash
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Evaluation of histone deacetylase inhibitory and antiproliferative activity of piperine and its derivatives [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 Piperine (1) was obtained from the seeds of Piper nigrum L. It could act as a pan-histone deacetylase (HDAC) inhibitor. This lead compound was structurally modified to six derivatives that exhibited improved HDAC inhibitory activity.
La-or Somsakeesit +6 more
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Indonesian Journal of Chemistry, 2022 The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT).
Gunasingham Parthiban +4 more
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Epigenetic regulation by gut microbiota
Gut Microbes, 2022 The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host.
Vivienne Woo, Theresa Alenghat
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Archives of Medical Science, 2021 Introduction The objective of this study was to explore the role of curcumin (CUR) in the control of renal cell carcinoma (RCC) as well as the molecular mechanism underlying the effect of CUR.
Fuhe Liu +7 more
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The efficacy of HDAC inhibitors in neoplasm treatment
Journal of Education, Health and Sport, 2020 Introduction and purpose: Histone Deacetylases (HDACs) are associated with epigenetic regulation of gene expression. They are responsible of adequate action of not only histone proteins, but also crucial cell cycle proteins, such as p53, NF‐κB or alpha ...
Dominika Psiuk +4 more
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