Results 11 to 20 of about 110,208 (302)

Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology Perspective [PDF]

Metabolites, 2021
Histone deacetylases (HDACs) are epigenetic enzymes that play a central role in gene regulation and are sensitive to the metabolic state of the cell. The cross talk between metabolism and histone acetylation impacts numerous biological processes including development and immune function.
Jacob King, Maya Patel, Sriram Chandrasekaran   +2 more
openaire   +3 more sources

HDACs and HDAC Inhibitors in Cancer Development and Therapy [PDF]

Cold Spring Harbor Perspectives in Medicine, 2016
Over the last several decades, it has become clear that epigenetic abnormalities may be one of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play a crucial role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear architecture.
Yixuan, Li, Edward, Seto
openaire   +2 more sources

Histone deacetylases (HDACs): characterization of the classical HDAC family [PDF]

Biochemical Journal, 2003
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational modification of histones, the building blocks of chromatin, such as methylation, phosphorylation and acetylation. Acetylation is probably the best understood of these modifications: hyperacetylation leads to an increase in ...
Annemieke J M, de Ruijter, Albert H, van Gennip, Huib N, Caron, Stephan, Kemp, André B P, van Kuilenburg   +4 more
openaire   +4 more sources

Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors

Molecules, 2020
The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and ...
Regina Martínez, Bruno Di Geronimo, Miryam Pastor, José María Zapico, Claire Coderch, Rostyslav Panchuk, Nadia Skorokhyd, Maciej Maslyk, Ana Ramos, Beatriz de Pascual-Teresa   +9 more
doaj   +1 more source

EPIGENETIC EFFECTS OF ENZASTAURIN – A NEW ASPECT IN THE MECHANISM OF ACTION OF AN ANTICANCER DRUG FROM PROTEIN KINASE INHIBITORS

Сибирский онкологический журнал, 2020
The purpose of the study was to analyze the ability of five antitumor drugs from the pharmaceutical group of protein kinase inhibitors (gefitinib, imatinib, pazopanib, ponatinib and enzastaurin) to reactivate the expression of the epigenetically silenced
V. P. Maksimova, J. V. Makus, O. G. Usalka, E. S. Lylova, P. E. Bugaeva, E. M. Zhidkova, D. A. Fedorov, O. P. Lizogub, E. A. Lesovaya, G. A. Belitsky, M. G. Yakubovskaya, K. I. Kirsanov   +11 more
doaj   +1 more source

HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag [PDF]

PeerJ, 2023
Purpose This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6brd1 mice, a model of retinitis pigmentosa (RP).
Yujie Dong, Jie Yan, Wenrong Xu, François Paquet-Durand, Zhulin Hu, Kangwei Jiao   +5 more
doaj   +2 more sources

Tumor Anti-Initiation and Anti-Progression Properties of Sulphated-Extract of Colocasia esculenta

Polish Journal of Food and Nutrition Sciences, 2021
Colocasia esculenta (Taro) is an edible tuberous plant; however, corms are its most worldwide consumed part while the corm powder is widely used in food industries. In this work, a sulphated polysaccharide extract of C.
Amira M. Gamal-Eldeen, Hassan Amer ‎, Cinderella A. ‎ Fahmy, Haytham ‎ Dahlawi, Basem H ‎ Elesawy, Nahla L. ‎ Faizo, Bassem M. ‎ Raafat   +6 more
doaj   +1 more source

HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases [PDF]

Chonnam Medical Journal, 2016
Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated in several pathophysiologic states.
Yoon, Somy, Eom, Gwang Hyeon
openaire   +2 more sources

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8.
Samir Mehndiratta, Mei-Chuan Chen, Yuh-Hsuan Chao, Cheng-Hsin Lee, Jing-Ping Liou, Mei-Jung Lai, Hsueh-Yun Lee   +6 more
doaj   +1 more source

Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy. [PDF]

, 2017
BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease ...
A Cevik, A Correa-Villasenor, A deAlmeida, A Granger, A Kulkarni, AP Vlahos, C Scholz, Carlin S Long, CL Antos, D Sedmera, DD Lemon, DJ Cao, Douglas D Lemon, J Lu, JP Cardinale, JW Newburger, JW Rossano, JW Rossano, Karin Nunley, Katharina M Lutter, KB Schuetze, Kimberly M Demos-Davies, KM Demos-Davies, M Tanno, MA Cavasin, MA Cavasin, Maria A Cavasin, MP Gupta, OA O'Connor, PA Marks, PC Frommelt, Q Yang, R Kirk, RG Ohye, S Chen, Sam Payne, SD Miyamoto, SD Miyamoto, SD Miyamoto, Shelley D Miyamoto, SJ Nakano, SK Mani, SM Williams, TA McKinsey, TG Gillette, Timothy A McKinsey, VM Klimek, Weston W Blakeslee, WJ Kowalski, WW Blakeslee   +49 more
core   +1 more source