Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo
A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng +8 more
wiley +1 more source
U-shaped and linear associations of ketogenic diet with nocturia and overactive bladder: mediation roles of frailty and platelet-to-HDL-C ratio and the influence of physical activity. [PDF]
Sun Y, Yin M, Zhou L.
europepmc +1 more source
Abstract Background Low‐carbohydrate diets (LCDs) are widely adopted for metabolic management, but their long‐term cardiometabolic effects in diverse populations remain unclear. We aimed to evaluate the association between self‐selected moderate LCD adherence and cardiometabolic parameters in individuals with and without diabetes.
Leticia Batista de Azevedo +3 more
wiley +1 more source
Association of HbA1c/HDL-C ratio and depression with cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study. [PDF]
Dong J +5 more
europepmc +1 more source
Adipose tissue as a potential reservoir for and modifier of SARS‐CoV‐2 infection and its complications. Schematic demonstrating the differences in subcutaneous and visceral adipose tissue and infection capacity of SARS‐CoV‐2 with interplay between macrophages and adipocytes as target cells for viral tropism.
Liam Charles Maher +2 more
wiley +1 more source
TG/HDL-C Ratio as a Superior Diagnostic Biomarker for Coronary Plaque Burden in First-Time Acute Coronary Syndrome. [PDF]
Aydin F, Murat B, Murat S, Dağhan H.
europepmc +1 more source
ABSTRACT Objective This study compared the effects of phentermine‐topiramate‐ER (mid‐dose 7.5/46 mg) versus placebo on weight loss and cardiovascular disease (CVD) risk outcomes when used as an adjunct to a digitally enhanced lifestyle intervention (DELI).
Alejandro Campos +15 more
wiley +1 more source
Data-driven analysis of the relationship between the HbA1c/HDL-C ratio and coronary artery calcification: a cross-sectional study. [PDF]
Chen C, Li M, Yan G, Zhang W, Tang C.
europepmc +1 more source
Moving Beyond LDL-C and Non-HDL-C: Apolipoprotein B as the Stronger Lipid-Related Predictor of Coronary Artery Disease in Statin-Treated Patients. [PDF]
Jigoranu RA +14 more
europepmc +1 more source

