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HDL and Sepsis

2022
Sepsis has been recognized as a global health burden in the year 2017 for its high morbidity and mortality. HDL, a cholesterol transporter, also plays vital role in inflammation besides its typical role in reverse cholesterol transportation. In septic patients, HDL levels dropped significantly.
Huanhuan, Cao, Wei, Huang
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HDL and Diabetes

2022
Diabetes is a worldwide public health issue, with the number of cases expected to reach 642 million by 2040. Patients with diabetes are at a two- to four-fold increased risk of developing cardiovascular disease. This chapter focuses on the anti-diabetic and cardioprotective functions of plasma high-density lipoproteins (HDLs).
Blake J, Cochran   +2 more
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HDL and Therapy

2022
A wealth of evidence indicates that high-density lipoprotein assumes the unique antiatherosclerosis and other cardioprotective properties. Based on that, HDL-C has been considered as a promising therapy target to reduce the cardiovascular diseases.
Ke, Li, Xianwei, Xie, Yansong, Guo
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HDL and ASCVD

2022
In this chapter, we summarize the relationship between circulating high-density lipoprotein (HDL) and atherosclerotic cardiovascular disease (ASCVD). HDL acts in many types of cells, such as endothelial cell, macrophage, T lymphocyte, etc. Recently, novel HDL-related therapies have been developed to treat ASCVD.
Hongtu, Cui, Qian, Du
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HDL and Oxidation

2022
In this chapter, we will focus on HDLs' activity of inhibiting LDL oxidation and neutralizing some other oxidants. ApoA-I was known as the main antioxidant component in HDLs. The regulation of antioxidant capacity of HDL is mainly exhibited in regulation of apoA-I and alterations at the level of the HDL lipidome and the modifications of the proteome ...
Qi, Zhang, Zongzhe, Jiang, Yong, Xu
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HDL Subfractions, HDL Receptors and HDL Turnover

1987
Plasma lipoproteins can be classified according to density, size or electrophoretic mobility. The latter is based on the apolipoprotein composition. Alaupovic1 proposed a distinction between so-called simple lipoproteins, containing only one apolipoprotein, and complex lipoproteins, containing more than one apolipoprotein. Recent publications show that
F.M. van 't Hooft   +3 more
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HDL and Surgery

2022
In addition to the well-known functions, plasma HDL also plays an important role in postsurgery periods. In this chapter, we summarized the changes of HDL after surgery like bariatric surgery and cardiac surgery. Not only the amount of HDL changed, the HDL components or functions have also been altered after various surgeries.
Yue-Ming, Peng, Jing-Song, Ou
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Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Journal of Cellular Physiology, 2018
Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be considered as a systemic process followed by an elevation of inflammatory mediators.
S. Ganjali   +6 more
semanticscholar   +1 more source

HDL and microRNAs

2022
In previous chapters, we know that high-density lipoproteins (HDLs) could act at multiple cell lines and then trigger intracellular molecular pathway to prevent several metabolic diseases. Besides the classic genes regulating cholesterol efflux and reverse cholesterol transport (RCT), microRNAs (miRNAs) could also affect HDLs biogenesis, metabolism ...
Hongtu, Cui, Kaixuan, Lv, Nana, Yang
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Is the antiatherosclerotic potency of HDL modulated by the origin of HDL?

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 1994
Different HDL preparations from rabbit blood were injected intravenously (10 mg HDL protein/injection and animal) into cholesterol fed rabbits twice a week for 8 weeks. The composition of the used high density lipoprotein (HDL) was modified by dietary pretreatment.
A. Beitz, Beitz J, H.-J. Mest
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