Results 61 to 70 of about 2,768,031 (303)

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

HUBUNGAN ANTARA AKTIVITAS FISIK DAN ANGKA KECUKUPAN GIZI MAKRONUTRIEN TERHADAP RASIO KOLESTEROL TOTAL/HDL PADA MASYARAKAT PEDESAAN

Jurnal Farmasi Sains dan Komunitas, 2017
Cardiovascular disease is the number one cause of death in the world. The diseaseis influenced by several factors such as lack of physical activity, imbalanced nutritional intake, and high blood cholesterol levels.
Utari Febrina Supomo Sunu, Galih Permadi, Fenty Fenty   +2 more
doaj   +1 more source

Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels [PDF]

, 2017
Background: Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor.
Kawashiri, Shin-Ya, Jun Koyamatsu, Nagayoshi, Mako, Yuji Shimizu, Koyamatsu, Jun, Mako Nagayoshi, Shimizu, Yuji, Maeda, Takahiro, Takahiro Maeda, Shin-Ya Kawashiri, Yamanashi, Hirotomo, Sato, Shimpei, Hirotomo Yamanashi, Kadota, Koichiro, Shimpei Sato, Koichiro Kadota   +15 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Dose‑dependent association of smoking exposure with HDL subfraction cholesterol content

Scientific Reports
Smoking has a significant effect on plasma lipid concentrations, especially high‑density lipoprotein (HDL)-associated cholesterol and its distribution across HDL subfractions, which are critical for cardiovascular health.
Péter Pikó, Nóra Kovács, László Pál, Sándor Szücs, Ildikó Seres, György Paragh, Róza Ádány   +6 more
doaj   +1 more source

Pathophysiology of elevated ascites fluid cholesterol in malignant ascites [PDF]

, 1992
The existence of marked elevations of ascitic fluid cholesterol has been observed in patients with peritoneal carcinomatosis compared to patients with cirrhosis and has been found useful in differential diagnosis.
Jüngst, Dieter, Gerbes, Alexander L., Xie, Yining   +2 more
core   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Analysis of Reference Range Values of Lipid Profile and Lipid Ratio in Healthy Young Adult Population in Makassar, Indonesia

National Journal of Community Medicine
Background: Lipids are essential for energy, hormones, digestion, and cell structure. A reference range of population-specific lipid profiles is essential due to variations. This study aimed to determine reference ranges for lipid profiles and ratios in
Syamsir syamsir, Liong Boy Kurniawan, Yuyun Widaningsih, Burhanuddin Bahar, Tenri Esa, Andi Ariyandy   +5 more
doaj   +1 more source

Measurement of Total Cholesterol, HDL-Cholesterol, and LDL-Cholesterol

Clinics in Laboratory Medicine, 1989
Plasma concentrations of LDL and HDL are generally measured in terms of their cholesterol content. This requires the separation of the appropriate lipoprotein-containing fractions. The separation and measurement of each fraction are described.
openaire   +2 more sources