Results 31 to 40 of about 12,859,612 (227)

PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite

Respiratory Research, 2021
Background The airway epithelial barrier function is disrupted in the airways of asthmatic patients. Abnormal mitochondrial biogenesis is reportedly involved in the pathogenesis of asthma.
Tsutomu Saito, Tomohiro Ichikawa, Tadahisa Numakura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Koji Murakami, Shun Yamanaka, Yusaku Sasaki, Yorihiko Kyogoku, Koji Itakura, Hirohito Sano, Katsuya Takita, Rie Tanaka, Tsutomu Tamada, Masakazu Ichinose, Hisatoshi Sugiura   +16 more
doaj   +1 more source

Diesel exhaust particles increase nasal symptoms and IL-17A in house dust mite-induced allergic mice

Scientific Reports, 2021
Diesel exhaust particles (DEPs), traffic-related air pollutants, are considered environmental factors adversely affecting allergic diseases. However, the immunological basis for the adjuvant effects of DEP in allergic rhinitis (AR) remains unclear ...
Hahn Jin Jung, Young-Kyung Ko, Woo Sub Shim, Hyun Jik Kim, Dong-Young Kim, Chae-Seo Rhee, Moo Kyun Park, Doo Hee Han   +7 more
doaj   +1 more source

Safety profile and immunological response of dual sublingual immunotherapy with house dust mite tablet and Japanese cedar pollen tablet

Allergology International, 2020
Background: There have been no studies of dual administration of sublingual immunotherapy (SLIT) tablets for perennial and seasonal allergic rhinitis. This trial (JapicCTI-184014) was conducted to investigate the safety profile and immunological response
Minoru Gotoh, Kimihiro Okubo, Atsushi Yuta, Yukiko Ogawa, Hitoshi Nagakura, Shigehiro Ueyama, Tomoyo Ueyama, Kayoko Kawashima, Masashi Yamamoto, Shigeharu Fujieda, Masafumi Sakashita, Hirokazu Sakamoto, Naruhito Iwasaki, Eri Mori, Tomonori Endo, Nobuo Ohta, Hiroshi Kitazawa, Mitsuhiro Okano, Mikiya Asako, Masami Takada, Tetsuya Terada, Yuko Inaka, Syuji Yonekura, Tomokazu Matsuoka, Shinya Kaneko, Hiroki Hata, Nagisa Hijikata, Hisataka Tanaka, Keisuke Masuyama, Yoshitaka Okamoto   +29 more
doaj   +1 more source

Crucial role of stimulator of interferon genes-dependent signaling in house dust mite extract-induced IgE production

Scientific Reports, 2021
Stimulator of interferon genes (STING) is a DNA sensor that responds to pathogens and induces type I interferon production. Herein, the role of STING in house dust mite extract (HDM)-induced allergic asthma was investigated.
Hiroki Nunokawa, Yusuke Murakami, Takashi Ishii, Tomoya Narita, Haruyuki Ishii, Hajime Takizawa, Naomi Yamashita   +6 more
doaj   +1 more source

Kajian Submodel Biaya Operasi Kendaraan Pada Model HDM-4 [PDF]

, 2020
Vehicle operating costs (BOK) are costs incurred to own and use vehicles, consisting of fixed costs and costs of movement. Motion costs are costs incurred for using a vehicle.
Santoso, Idwan, Pentury, Christopher, Wibowo, Sony Sulaksono   +2 more
core  

Plan de mantenimiento periódico del pavimento en el tramo Paradero Las Retamas – Puente Los Ángeles

Infraestructura Vial, 2023
El presente estudio tuvo como objetivo general diseñar un plan de mantenimiento periódico para la prolongación de la vida útil del pavimento en el tramo Paradero Las Retamas – Puente Los Ángeles de la carretera Central, elaborado en el 2021.
Daniel Alexis Ramirez Medina, Luis Segundo Valenzuela Robles   +1 more
doaj   +1 more source

Calibration study of HDM-4 Model of structural cracking models for flexible pavements in Moroccan Context

, 2015
International audienceLe présent travail a pour objet, l'étude de calage du sous-modèle de fissuration structurelle qui a une influence assez notable sur le processus de détérioration des chaussées routières, pour ce faire on est basé sur l'exploitation ...
Lamrini, Bouchra,, BANNOUR, ABDELILAH, El Khadir, LAKHAL, Joubert, pierre,, Elomari, Mohamed, AFECHKAR, Mohamed,   +5 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo

Respiratory Research, 2019
Background Antiviral drugs such as rupintrivir may have an immune-modulatory effect in experimentally induced allergic asthma with subsequent RV infection.
Olga Danov, Lisa Lasswitz, Helena Obernolte, Christina Hesse, Armin Braun, Sabine Wronski, Katherina Sewald   +6 more
doaj   +1 more source