Results 41 to 50 of about 12,859,612 (227)

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Analiza občutljivosti HDM-4 modelov propadanja vozišč [PDF]

, 2016
Občutljivost HDM-4 modelov propadanja vozišč je sicer že prikazana v dokumentaciji HDM-4 paketa, a zgolj na kvalitativnem nivoju. Namen te naloge pa je, da kvantitativno ocenimo elastičnost modelov na spremembe nekaterih ključnih parametrov. V tej nalogi
Farhad Skandary, Ahmad
core  

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source

The impact of urbanization and wealth on house dust mite sensitization in children from north-central Nigeria

Italian Journal of Pediatrics, 2022
The impact of socio-economic status on the risk of allergy in African children is not clear. This was a cross sectional study including children aged 6–14 years from urban and rural settings in north-central Nigeria.
Chiara Zuiani, Michele Arigliani, Ramatu Zubair, Livingstone Gayus Dogara, Luigi Castriotta, Ashel Dache Sunday, Reward Christopher Audu, Habibah Dadan-Garba, Zakary Sani, Baba Inusa, Paola Cogo   +10 more
doaj   +1 more source

Interactions between maternal provisioning and natural selection on seed mass fluctuate across heat waves

American Journal of Botany, EarlyView.
Abstract Premise Changing climates are leading to more frequent and severe heat waves, potentially threatening plant populations. Both acclimation to stress and selection for heat‐escape or heat‐resistance phenotypes occur during heat waves. However, plastic responses and selection do not necessarily interact cohesively—even producing trait responses ...
Lana F. Gaspard, Elissa Harb, Stacy D. Holt Jr., Courtney M. Patterson, Nicholas J. Kooyers   +4 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Adaptation of HDM-4 Tool for Strategic Analysis of Urban Roads Network

Transportation Research Procedia, 2016
Abstract The Urban roads constitute about 9.0% (4.11 lakh kms) of the total road length in India. The urban roads especially in metropolitan cities carry a huge traffic volume which affects the road condition adversely. The other factors responsible for poor roads in urban areas are the problem of overloading, encroachment on the road land and ribbon
Yogesh, U. Shah, Jain, S.S., Devesh, Tiwari   +2 more
openaire   +1 more source

Paradoxical effects of rapamycin on experimental house dust mite-induced asthma. [PDF]

PLoS ONE, 2012
The mammalian target of rapamycin (mTOR) modulates immune responses and cellular proliferation. The objective of this study was to assess whether inhibition of mTOR with rapamycin modifies disease severity in two experimental murine models of house dust ...
Karin Fredriksson, Jill A Fielhaber, Jonathan K Lam, Xianglan Yao, Katharine S Meyer, Karen J Keeran, Gayle J Zywicke, Xuan Qu, Zu-Xi Yu, Joel Moss, Arnold S Kristof, Stewart J Levine   +11 more
doaj   +1 more source

Exact Values and Bounds on Covering Schemes of Strength Two

Journal of Combinatorial Designs, EarlyView.
ABSTRACT In this work, we investigate covering schemes of strength 2 over finite abelian groups, establishing new lower and upper bounds and evaluating new exact values. A main result is a new general lower bound that improves the trivial one and achieves optimality for the binary case. We also develop a recursive relation based on subsets of the group
André G. Castoldi, Anderson N. Martinhão, Emerson L. Monte Carmelo, Pablo H. Perondi, Otávio J. N. T. N. dos Santos   +4 more
wiley   +1 more source

Prenatal and Postnatal Cigarette Smoke Exposure Is Associated With Increased Risk of Exacerbated Allergic Airway Immune Responses: A Preclinical Mouse Model

Frontiers in Immunology, 2021
Increased exposure to household air pollution and ambient air pollution has become one of the world’s major environmental health threats. In developing and developed countries, environmental cigarette smoke (CS) exposure is one of the main sources of ...
Hamed Janbazacyabar, Jeroen van Bergenhenegouwen, Jeroen van Bergenhenegouwen, Johan Garssen, Johan Garssen, Thea Leusink-Muis, Ingrid van Ark, Marthe T. van Daal, Gert Folkerts, Saskia Braber   +9 more
doaj   +1 more source