Results 181 to 190 of about 108,215 (261)

Development of efficient targeted insertion mediated by CRISPR-Cas12a and homology-directed repair in maize. [PDF]

Front Genome Ed
Barco B, Dong S, Matsuba Y, Crook A, Xu R, Zhang Y, Zhang C, Carlin R, Potter K, Rigoulot SB, Park J, Seaberry EM, Parrish A, Elumalai S, Nalapalli S, Schuller C, Prairie A, Mangum A, Mei K, Wu H, Murray M, Setliff K, Johnson F, McNamara D, Zhu L, Rose M, Gu W, Hu H, Zhang Y, Jiang Y, Wang W, Tang G, Geng L, Xu J, Shi W, Nichols J, Kelliher T, Shi L, Jepson I, Que Q.   +39 more
europepmc   +1 more source

Impact of rectal gas evacuation on dosimetry and applicator displacement in cervical cancer brachytherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 2, February 2026.
Abstract Objective This study aimed to evaluate the impact of rectal gas evacuation on organ‐at‐risk (OAR) volumes, dose‐volume histogram (DVH) parameters, and applicator displacement during cervical cancer brachytherapy. Methods Twenty‐one cervical cancer patients who received three‐dimensional brachytherapy at our center between November and December
Haiyan Wu, Chengdian he, Mei Liu, Xiujuan Zhao   +3 more
wiley   +1 more source

Optimization of donor structure enhances the generation of cloned goats with high expression of human butyrylcholinesterase by CRISPR/Cas9. [PDF]

Front Bioeng Biotechnol
Wu Y, Zheng J, Chen J, Sun T, Luan T, Li Y, Fa Y, Qiu Y, Zhang R.   +8 more
europepmc   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

SSA-mediated selection marker gene activation enhances relative gene targeting efficiency in plants. [PDF]

Hortic Res
Kong D, Cheng Y, Ke Y, Dang X, Liu X, Wang C, Huang C, Ye R, Miki D.   +8 more
europepmc   +1 more source

Mechanisms of Direct Electron Transfer Governed by Redox‐Active Conductive Carrier with Superior Wettability in Anaerobic Biofilms

Advanced Science, Volume 13, Issue 8, 9 February 2026.
A redox‐active conductive carrier of tannic acid‐modified iron‐biochar with superior wettability is demonstrated to regulate direct electron transfer at the anaerobic biofilm‐carrier interface by enhancing the cytochrome c‐mediated pathway. For the first time, integrated evidence from spectroscopy, electrochemical analyses, and metatranscriptomics ...
Junli Tian, Xiaoyuan Zhang, Lulu Xing, Bin Ji, Jinfeng Lu, Yu Liu   +5 more
wiley   +1 more source

Comparative study of dosimetry and treatment outcome of two different dose fractionation schedules of high dose rate intracavitary brachytherapy in locally advanced cancer cervix. [PDF]

Rep Pract Oncol Radiother
Jaiswal K, Batham S, Ghosh A, Gupta S, Gupta R, Rijin NT, Srivastava S, Singh N, Negi MPS, Bhosale VV.   +9 more
europepmc   +1 more source

Functional outcomes and toxicity following focal low‐dose‐rate brachytherapy for low–intermediate risk prostate cancer

BJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objectives We aim to prospectively evaluate functional outcomes and toxicity following focal low‐dose‐rate (LDR) brachytherapy for low–intermediate risk prostate cancer (PCa). Patients and Methods LIBERATE is a clinical registry of men treated with focal LDR brachytherapy for low–intermediate risk PCa since September 2019.
Mohammadmehdi Adhami, Jeremy Cheng, Elliot Anderson, Lloyd Smyth, Cate Davey, Thang Nguyen, Richard O'Sullivan, Andrew Ryan, Nathan Lawrentschuk, Jeremy Grummet, Andrew See   +10 more
wiley   +1 more source

CRISPR-Cas9 HDR optimization: RAD52, denatured, and 5'-modified DNA templates in knock-in mice generation. [PDF]

iScience
Skryabin BV, Braun DA, Kaiser H, Gubar L, Seeger B, Khanam T, Stegemann A, Pavenstädt H, Rozhdestvensky TS.   +8 more
europepmc   +1 more source

Comparative Efficacy and Safety of Ketamine Versus Midazolam for Suicidality: A GRADE‐Assessed Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Brain and Behavior, Volume 16, Issue 2, February 2026.
Ketamine rapidly reduced suicidal ideation and depressive symptom severity more than midazolam in adults with acute suicidality across 10 RCTs (n = 649). Transient adverse effects (e.g., nausea, derealization, dizziness) were more frequent with ketamine, supporting its use as a fast‐acting emergency intervention with safety monitoring.
Asim Shah, F. N. U Sawaira, Misbahuddin, Muneeb Shad Mohmand, Suleman Khan, Zaryab Bacha, Hammad Iftikhar, Asad Jamal, Fazia Khattak, Aizaz Anwar Khalid, Aamer Syed, Kamil Ahmad Kamil   +11 more
wiley   +1 more source