Results 131 to 140 of about 27,616 (251)

Impact of variation in the α/β of cervical cancer on predicted clinical outcomes

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Background To improve the effectiveness and efficiency in radiation therapy, various treatment modalities and fractionation schemes have been introduced and combined for cancer treatment. Biological effective dose (BED) and equivalent dose in 2 Gy fraction (EQD2) are used to evaluate and compare different modalities and fractionations and also
Cameron Thayer‐Freeman, Brien Washington, Dennis Cheek, Wei Luo   +3 more
wiley   +1 more source

Beyond TG‑43: A PRISMA‐based systematic review on model‐based dose‐calculation algorithms in brachytherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Background and purpose The AAPM TG‐43 formalism has long served as the clinical standard for brachytherapy dose calculation but assumes a homogeneous water equivalent medium, overlooking limited scattering conditions and tissue heterogeneities.
Dat Tran, Thanh‐Tai Duong, Shada Wadi‐Ramahi, David Bradley, James C. L. Chow   +4 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Prognostic Factors in Oropharyngeal Cancer Treated With Definitive Chemoradiotherapy

Cancer Medicine, Volume 15, Issue 5, May 2026.
We studied 630 OPSCC patients treated with chemoradiotherapy in our institute. There was a low incidence of HPV‐associated OPSCC in our cohort. Tobacco remains the main etiological factor in our cohort. HPV status by p16 IHC, T stage, RT technique, and RT doses were independent prognostic factors for OPSCC patients.
Sheetal R. Kashid, Ashwini Budrukkar, Monali Swain, Sarbani Ghosh Laskar, Vedang Murthy, Tejpal Gupta, Ajay Sasidharan, Vijay Patil, Amit Joshi, Vanita Noronha, Neha Mittal, Manoj Mahimkar, Asawari Patil, Usha Patel, Shwetabh Sinha, Anuj Kumar, Nandini Menon, Munita Bal, Kumar Prabhash, Jai Prakash Agarwal   +19 more
wiley   +1 more source

A Novel Strategy to Produce CAR‐γδ T Cells via Site‐Directed Gene Integration by a Combination of CRISPR/Cas9 and AAV

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Chimeric antigen receptor (CAR)‐αβ T cells are commonly employed in tumor therapy but hindered by some limitations. γδ T cells are promising substrates for CAR therapy for their major histocompatibility complex (MHC)‐unrestricted recognition manner and innate immune function.
Ruoyu Dong, Yixi Zhang, Guangxun Yuan, Xiaoyan Yue, Yingying Ding, Xun Zeng, Haowen Xiao   +6 more
wiley   +1 more source

Scaling Lightness and Chroma for Highlight Stimuli in HDR Scenes

Color Research &Application, Volume 51, Issue 3, May/June 2026.
Chroma of a stimulus, whose (u′, v′) chromaticities are (0.2011, 0.4684) and have around 1 JNCD (Δu′v′ = 0.0033) to the D65 chromaticities, with the luminance from 0 to 10 000 cd/m2, as calculated using the six models. ABSTRACT Lightness and chroma, which are the key elements in uniform color spaces (UCS) and color appearance models (CAM), play ...
Yuetong Shen, Jiamin Guo, Minchen Wei
wiley   +1 more source

A Novel PTPN2 Isoform Differentially Regulates Immune Response

European Journal of Immunology, Volume 56, Issue 5, May 2026.
The A allele of the intronic SNP rs80262450 in the PTPN2 gene favors the expression of the splicing isoform PTPN2.4. This cytoplasmic isoform enhances TNF‐α production in myeloid cells, thereby contributing to intestinal inflammation. These findings identify PTPN2.4 as a key pathogenic regulator and potential therapeutic target for inflammatory bowel ...
Xiaoguang Li, Fedik Rahimov, Rui Wang, Lei Gao, Renze Ma, Tiankai Han, Yingtao Bi, Freidrich Cruz, Jing Wang, Shaun Grosskurth, Elizabeth Asque, Jesus Paez‐Cortez, Marc C. Levesque, Nancy E. Crosbie, Timothy Radstake, Amlan Biswas, Kanstantsin Katlinski   +16 more
wiley   +1 more source

Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons

European Journal of Pain, Volume 30, Issue 5, May 2026.
ABSTRACT Introduction Understanding the molecular architecture of peripheral sensory neurons is critical as we pursue novel drug targets against pain and neuropathy. Sensory neurons in the dorsal root ganglion (DRG) show extensive compartmentalization; thus, understanding each compartment—from the peripheral to central terminals—is key to this effort ...
Julia R. Sondermann, Allison M. Barry, Feng Xian, Thomas Haberl, David Gomez‐Varela, Fritz Benseler, Dietmar Schreiner, Nils Brose, Noa Lipstein, Manuela Schmidt   +9 more
wiley   +1 more source

Next‐Generation Sustainable Food Production Through Integrative Biotechnology, AI, and Climate‐Resilient Innovations

Food and Energy Security, Volume 15, Issue 3, May/June 2026.
ABSTRACT By 2050, the global population is projected to reach ~10 billion, leading to 50% increase in food demand. This growth will place immense pressure on agricultural systems that are already struggling with the impacts of climate change and resource depletion.
Chaquayla Katam, Hajra Maqsood, Brooke Bucci, Sixue Chen   +3 more
wiley   +1 more source

Morphology and Distribution of Olfactory Receptor Neurons in Southern Bluefin Tuna, Thunnus maccoyii (Teleostei): Implications for Olfactory Hydrodynamics

Journal of Morphology, Volume 287, Issue 5, May 2026.
The number and distribution of olfactory receptors over the olfactory lamellar surface of four juvenile southern bluefin tuna were quantified using scanning electron microscopy. The microvillous olfactory receptors (mORN) are concentrated in the rostral region of the lamellar surface, while ciliated olfactory receptors (cORN), which are dominant in ...
Myoung‐Hoon Ha, Lucille Chapuis, Travis L. Dutka, Julian Pepperell, Caroline C. Kerr, Shaun P. Collin   +5 more
wiley   +1 more source