Results 91 to 100 of about 8,773,508 (347)

First Class Call Stacks: Exploring Head Reduction [PDF]

, 2016
Weak-head normalization is inconsistent with functional extensionality in the call-by-name $\lambda$-calculus. We explore this problem from a new angle via the conflict between extensionality and effects.
Ariola, Zena M., Downen, Paul, Johnson-Freyd, Philip   +2 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Crossover to self-organized criticality in an inertial sandpile model [PDF]

, 1996
We introduce a one-dimensional sandpile model which incorporates particle inertia. The inertial dynamics are governed by a new parameter which, as it passes through a threshold value, alters the toppling dynamics in such a way that the system no longer ...
Head, DA, Rodgers, GJ
core   +5 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Face scabies in the elderly: when dermoscopy can be a game changer

Dermatology Reports
Dear Editor, Scabies is a common pruritic ectoparasitic infestation of the skin caused by the mite Sarcoptes scabiei. It classically presents as an intensely pruritic eruption that usually involves hands and interdigital folds, wrists, axillae ...
Andrea Corio, Enrico Zelin, Vanessa Mazzoletti, Benedetta Sonego, Camilla Brunello, Nicola di Meo, Iris Zalaudek   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Compounding and variational morphology: the analysis of inflection in Spanish compounds

Borealis: An International Journal of Hispanic Linguistics, 2014
This paper analyzes the morphological variation related to gender and number in Spanish compounding such as plural noun in [V+N]ncompounds (ellavaplatos, not el lavaplato; el cazamariposas, not *el cazamariposa), the gender and number asymmetries between
Cristina Buenafuentes
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Head to head polymers

Progress in Polymer Science, 1999
Abstract Pure head to head (H–H) addition polymers, such as H–H polyolefins, H–H acrylates and H–H poly(vinyl halides), have been of interest for the understanding of the structure/properties relationship of addition polymers. These polymer structures have provided challenges of synthesis, characterization and of the measurements of their mechanical ...
O. Vogl, M.F. Qin, A. Zilkha
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source