Results 81 to 90 of about 7,002,290 (342)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Psychological Factors and Treatment Adherence Behavior in Patients With Chronic Heart Failure [PDF]

, 2007
Background: Chronic heart failure adversely affects 300,000 Australians. Symptom stabilization and prognosis are partially determined by patients following medical and lifestyle recommendations.
Dwyer, Jonathan, Head, Kathryn, Schweitzer, Robert   +2 more
core   +2 more sources

ІСТОРІЯ РОЗВИТКУ КАФЕДРИ СОЦІАЛЬНОЇ МЕДИЦИНИ ТА ОРГАНІЗАЦІЇ ОХОРОНИ ЗДОРОВ'Я БУКОВИНСЬКОГО ДЕРЖАВНОГО МЕДИЧНОГО УНІВЕРСИТЕТУ / History of Department of Social Medicine and Healthcare of the Bukovinian State Medical University

Актуальні питання суспільних наук та історії медицини, 2015
Ревенко Ж., Чебан В., Ясинская Э. История развития кафедры социальной медицины и организации здравоохранения Буковинского государственного медицинского университета. Описываются этапы развития и характерные особенности деятельности кафедры.
Чебан Василь, Ясинська Ельвіра, Ревенко Жанетта   +2 more
doaj  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Early-Middle Pleistocene transitions: Linking terrestrial and marine realms [PDF]

, 2015
Marked by a progressive increase in the amplitude of climate oscillations and a shift towards a quasi-100 kyr frequency, the Early–Middle Pleistocene transition (EMPT), previously known as the Mid-Pleistocene Transition (or Mid-Pleistocene Revolution) (1.
Gibbard, Philip L., Head, Martin J.
core   +3 more sources

Intra-rater and Inter-rater Reliability and Agreement of the Scapular Dyskinesis test in Young Men with Forward Head and Round Shoulder Posture

Journal of Rehabilitation Sciences and Research, 2019
Background: Forward head and round shoulder posture (FHRSP) is believed to be related to scapular dyskinesis (SD), placing increased stress on the neck and shoulder, leading to pain and dysfunction.
Mohammad Bayattork, Foad Seidi , Hooman Minoonejad , Philip McClure , Esmaeil Mozafaripoor   +4 more
doaj  

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source