Results 81 to 90 of about 1,585,150 (380)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Abducens Nerve Neuropraxia due to Acute Bacterial Rhinosinusitis: Case Report and Literature Review

Case Reports in Otolaryngology, 2023
Background. Acute bacterial rhinosinusitis (ABRS) is a common infection of the paranasal sinuses that can lead to complications such as orbital and intracranial extension. The abducens nerve course is adjacent to the sphenoid sinus.
Abdulrahman Alghulikah, Sarah Alseneidi, Hedayah Alsaady, Ahmed Alhussien, Surayie Al-Dousary, Saud Alromaih, Abdulrahman AlHumaizi   +6 more
doaj   +1 more source

Chondrosarcoma of the Head and Neck

Yonsei Medical Journal, 2005
Chondrosarcoma of the head and neck region is a rare disease, representing approximately 0.1% of all head and neck neoplasms. The 5-year survival rate of chondrosarcoma is 70-80%, showing relatively good prognosis; however, it is known to progress slowly and eventually cause multiple metastases.
Young Chang Lim, Jae Yeon Seok, Mee Hyun Song, Won Sang Lee, Eun Chang Choi, Sei Young Lee   +5 more
openaire   +4 more sources

EPIDEMIOLOGICAL STUDY ON HEAD AND NECK MALIGNANCIES - A STUDY OF 150 CASES [PDF]

, 2013
OBJECTIVE: In the present study we investigate the head and Neck Malignancy cases presenting to the ENT department of our Hospital, and analyze the same to give inputs as to the incidence of head and neck malignancies, the symptoms and stage of ...
Gopalakrishnan, SankaraNarayanan, Kumar, Praveen   +1 more
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Chinese guideline for the diagnosis and treatment of juvenile‐onset recurrent respiratory papillomatosis (2024)

Pediatric Investigation
The incidence of juvenile‐onset recurrent respiratory papillomatosis (JORRP) varies worldwide, and the lack of well‐adopted guidelines for use in China suggests that patients with JORRP do not receive optimal care.
Working Group of Chinese Guideline for the Diagnosis and Treatment of JORRP, Subspecialty Group of Pediatrics, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery   +2 more
doaj   +1 more source

Education of trainees, training and fellowships for head and neck oncologic and surgical training in the UK:United Kingdom National Multidisciplinary Guidelines [PDF]

, 2016
Since the previous edition of these guidelines, significant changes have taken place in the training and assessment of surgeons and oncologists who treat patients with head and neck cancer.
Matteucci, P., Niblock, P., Robson, A., Simo, R., Woodwards, B.   +4 more
core   +3 more sources

Clinical update on head and neck cancer: molecular biology and ongoing challenges

Cell Death and Disease, 2019
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies, surgery and radiotherapy represent the primary treatment options for most ...
E. Alsahafi, K. Begg, I. Amelio, N. Raulf, P. Lucarelli, T. Sauter, M. Tavassoli   +6 more
semanticscholar   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Oral Metastasis From Colorectal Adenocarcinoma: Report of a New Case and a Scoping Review

Case Reports in Dentistry
Clinical Relevance: Because of the rarity of oral metastasis and possible variations in the clinical and histological presentations, correct diagnosis can be challenging and requires careful clinical and histopathological evaluations with adjuvant ...
Gioele Gioco, Romeo Patini, Denise Marchesini, Cosimo Rupe, Edoardo Staderini, Alberta Lucchese, Eugenio De Corso, Carlo Lajolo   +7 more
doaj   +1 more source