Results 21 to 30 of about 275,762 (263)

Demographics and access to head and neck cancer care in rural areas compared to urban areas in Germany

Cancer Medicine, 2023
Background Demographic development in rural and urban areas differs substantially. Demographics and access to specialized head and neck cancer centers may affect head and neck cancer patients' (HNCP) outcomes.
Julius M. Vahl, Gabriele Nagel, Ayla Grages, Matthias Brand, Adrian vonWitzleben, Michael Sonntag, Marie‐Nicole Theodoraki, Jens Greve, Tsima Aboukors, Michael Denkinger, Dhayana Dallmeier, Christian Idel, Thomas K. Hoffmann, Simon Laban   +13 more
doaj   +1 more source

The roles of extracellular vesicles in the development, microenvironment, anticancer drug resistance, and therapy of head and neck squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Head and neck squamous cell carcinoma (HNSCC) is one of the main malignant tumours affecting human health, mainly due to delayed diagnosis and high invasiveness.
Xueying Wang, Junnan Guo, Pingyang Yu, Lunhua Guo, Xionghui Mao, Junrong Wang, Susheng Miao, Ji Sun   +7 more
doaj   +1 more source

Head and Neck Cancers [PDF]

Journal of the National Comprehensive Cancer Network, 2011
Overview This shortened version of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck (H&N) Cancers addresses tumors arising in the oral cavity, oropharynx, hypopharynx, and nasopharynx (see Figure 1).1 Other types of H&N cancer (e.g., lip, larynx, paranasal sinus, salivary gland, mucosal melanoma, and occult primary ...
David G, Pfister, Kie-Kian, Ang, David M, Brizel, Barbara A, Burtness, Anthony J, Cmelak, A Dimitrios, Colevas, Frank, Dunphy, David W, Eisele, Jill, Gilbert, Maura L, Gillison, Robert I, Haddad, Bruce H, Haughey, Wesley L, Hicks, Ying J, Hitchcock, Merrill S, Kies, William M, Lydiatt, Ellie, Maghami, Renato, Martins, Thomas, McCaffrey, Bharat B, Mittal, Harlan A, Pinto, John A, Ridge, Sandeep, Samant, Giuseppe, Sanguineti, David E, Schuller, Jatin P, Shah, Sharon, Spencer, Andy, Trotti, Randal S, Weber, Gregory T, Wolf, Frank, Worden   +30 more
openaire   +2 more sources

Regional outcome disparities in German head and neck cancer patients: Shorter survival in Eastern Germany

Cancer Medicine, 2023
Introduction Demographics are important prognostic factors in malignant diseases. A nationwide analysis concerning the prognostic impact of demographics in head and neck cancer (HNC) patients (HNCP) has not been performed previously.
Julius M. Vahl, Gabriele Nagel, Tsima Abou Kors, Matthias Brand, Adrian vonWitzleben, Michael Sonntag, Ayla Grages, Marie N. Theodoraki, Jens Greve, Michael Denkinger, Dhayana Dallmeier, Christian Idel, Stephan Stilgenbauer, Thomas K. Hoffmann, Simon Laban   +14 more
doaj   +1 more source

Loss of PIM1 correlates with progression and prognosis of salivary adenoid cystic carcinoma (SACC)

Cancer Cell International, 2018
Background Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC).
Jiajie Xu, Xin Zhu, Qingling Li, Chao Chen, Zhenying Guo, Zhuo Tan, Chuanming Zheng, Minghua Ge   +7 more
doaj   +1 more source

Head and neck cancer

The Lancet, 2008
Most head and neck cancers are squamous cell carcinomas that develop in the upper aerodigestive epithelium after exposure to carcinogens such as tobacco and alcohol. Human papillomavirus has also been strongly implicated as a causative agent in a subset of these cancers. The complex anatomy and vital physiological role of the tumour-involved structures
Athanassios, Argiris, Michalis V, Karamouzis, David, Raben, Robert L, Ferris   +3 more
openaire   +3 more sources

Comparison of surgical outcomes between patients undergoing trans-oral endoscopic thyroid surgery combined with trans-thoracoareolar approach and conventional open surgery

Frontiers in Surgery, 2022
Over the past decades, remote-access thyroid surgery has been widely developed in the treatment of thyroid carcinoma, which can help patients to avoid cosmetically displeasing scarring.
Youyuan Shi, Lu Zhang, Chang Liu, Yong Wang, Hailin Zhang, Xiuan Lin   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Developing a thyroid cancer differentiation state classification system using deep residual networks and metabolic signature profiling

npj Digital Medicine
We developed a deep residual network (ResNet) framework to classify thyroid cancer differentiation states by integrating multiomic data and interpretability analysis.
Yanzhi Zhang, Xiaoxue Du, Sijia Cai, Yiming Cao, Dan Zhao, Weibo Xu, Tian Liao, Ning Qu, Rongliang Shi, Qinghai Ji, Ben Ma, Yu Wang   +11 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source