Results 41 to 50 of about 315,615 (312)

European Head and Neck Society recommendations for head and neck cancer survivorship care

, 2022
Survivors of head and neck cancer can experience long-term consequences of the cancer and subsequent treatments even after the cancer has resolved. Increasingly clinicians are aware of the social, psychological, financial, and emotional impacts of these ...
Machczynski, Piotr, Singer, Susanne, Dawson, C., Eriksen, J.G., Ana Varges Gomes, Golusinski, Wojciech, Laverty, D.P., Simon, C., Licitra, Lisa, Licitra, L., Lisa Licitra, Golusinski, W., Hosal, Sefik, C. René Leemans, Charis Girvalaki, Machczynski, P., Jesper Grau Eriksen, Girvalaki, Charis, Dominic P. Laverty, Verdonck-de Leeuw, I., Dawson, Camilla, Hosal, S., Piotr Machczynski, Verdonck-de Leeuw, I.; id_orcid, Christian Simon, Leemans, C. René, Varges Gomes, A., Varges Gomes, Ana, Girvalaki, C., Irma Verdonck-de Leeuw, Leemans, C.R., Eriksen, Jesper Grau, Sefik Hosal, Singer, S., Simon, Christian, Susanne Singer, Wojciech Golusinski, Laverty, Dominic P., Verdonck-de Leeuw, Irma, Camilla Dawson   +39 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Head and neck cancers in Australia [PDF]

, 2014
This report on head and neck cancers in Australia presents the latest available information on incidence, mortality, survival and hospitalisations. Overview Head and neck cancer is a term used to describe a range of cancers that occur in the throat ...

core  

Developing a thyroid cancer differentiation state classification system using deep residual networks and metabolic signature profiling

npj Digital Medicine
We developed a deep residual network (ResNet) framework to classify thyroid cancer differentiation states by integrating multiomic data and interpretability analysis.
Yanzhi Zhang, Xiaoxue Du, Sijia Cai, Yiming Cao, Dan Zhao, Weibo Xu, Tian Liao, Ning Qu, Rongliang Shi, Qinghai Ji, Ben Ma, Yu Wang   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Long noncoding RNA RP11‐547D24.1 regulates proliferation and migration in papillary thyroid carcinoma: Identification and validation of a novel long noncoding RNA through integrated analysis of TCGA database

Cancer Medicine, 2019
Long noncoding RNAs (lncRNAs) are known to be key regulators of numerous biological processes, and substantial evidence supports that abnormal lncRNA expression plays a significant role in tumorigenesis and tumor progression.
Kai Guo, Lili Chen, Yunjun Wang, Kai Qian, Xiaoke Zheng, Wenyu Sun, Tuanqi Sun, Yi Wu, Zhuoying Wang   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Head and neck cancer

Journal of the Royal College of Physicians of Edinburgh, 2010
Head and neck cancer is traditionally thought of as being a disease associated with alcohol and tobacco abuse and deprivation. It was the fourth most common cancer in males in Scotland in 2000 and just over 1,000 cases were diagnosed in 2007. As smoking becomes less prevalent, a fall in the incidence of head and neck cancer could be anticipated ...
Emily, Crozier, Baran D, Sumer
openaire   +4 more sources

The KRT15 and KRT81 complex promotes lenvatinib resistance in thyroid cancer by upregulating DGKB mediated lipid metabolism

Scientific Reports
Lenvatinib resistance is a major clinical obstacle in the treatment of radioiodine-refractory papillary thyroid cancer (PTC). Clarification of the molecular mechanisms of this resistance is of utmost importance to devise effective therapeutic strategies.
Yunjun Wang, Yu Zhang, Dan Zhao, Yi Wu, Tian Liao, Yu Wang, Jun Xiang, Qi Chen, Tuanqi Sun   +8 more
doaj   +1 more source