Results 171 to 180 of about 365 (207)

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

open access: yesAdvanced Science, EarlyView.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones   +5 more
wiley   +1 more source

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

open access: yesAdvanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu   +5 more
wiley   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

open access: yesAdvanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu   +10 more
wiley   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

open access: yesAdvanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang   +8 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

open access: yesAdvanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya   +10 more
wiley   +1 more source
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A model of the rodent head direction system that accounts for unique properties of anterior thalamic head direction cells

Neurocomputing, 1999
Abstract We present a model of the rat head direction cell circuit that accounts for the recently discovered bimodality and distortion observed in the tuning curves of anterior thalamic head direction cells. This model also explains why anterior thalamic head direction cells show a constant amount of anticipation across all angular velocities.
David Touretzky, Jeremy P Goodridge
exaly   +2 more sources

Interspike interval analysis and spikelets in presubicular head-direction cells

Journal of Neurophysiology, 2018
Head-direction (HD) neurons are thought to provide the mammalian brain with an internal sense of direction. These cells, which selectively increase their firing when the animal’s head points in a specific direction, use the spike rate to encode HD with a high signal-to-noise ratio.
Andrea Burgalossi   +2 more
exaly   +4 more sources

A neuromorphic head direction cell system

2009 IEEE International Symposium on Circuits and Systems, 2009
The head direction (HD) cell system in the brain of mammals is thought to be part of the neural circuitry supporting their spatial navigation capabilities. In this paper we present a neuromorphic VLSI system that mimics the operation of the HD system. Relying on spiking neurons and attractor dynamics, this system can be used to represent and retain the
Tarek M. Massoud, Timothy K. Horiuchi
openaire   +1 more source

Head direction cells in the primate pre-subiculum

Hippocampus, 1999
The function of the primate hippocampus and related structures was analysed by making recordings from the hippocampus, subiculum, presubiculum, and parahippocampal gyrus in monkeys actively walking in the laboratory. Head direction cells were found in the presubiculum.
R G, Robertson   +3 more
openaire   +2 more sources

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