Results 231 to 240 of about 581,430 (272)

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Entorhinal cortex represents task-relevant remote locations independently of CA1. [PDF]

Nat Neurosci
Aery Jones EA, Low IIC, Cho FS, Giocomo LM.   +3 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Non-Canonical Subiculum Circuit Organization and Function. [PDF]

Hippocampus
Gao P, Cao W, Nitz DA, Xu X.
europepmc   +1 more source

Design of an automated cell batch microinjection system based on magnetic tweezers for zebrafish embryos. [PDF]

Microsyst Nanoeng
Guo X, Wang F, Zhao A, Zhang Y, Jiang H, Knoll A, Shen M, Lv F, Zhou M.   +8 more
europepmc   +1 more source

Deep critical zone controls on shallow landslides. [PDF]

Proc Natl Acad Sci U S A
Moon S, Formetta G, Higa JT, Busti R, Bellugi DG, Milledge DG, Ebel BA, Dietrich WE.   +7 more
europepmc   +1 more source

A dual-color miniature endoscope for calcium imaging in behaving mice. [PDF]

iScience
Zhang J, Hong F, Kim J, Bakhurin K, Kim N, Yin HH.   +5 more
europepmc   +1 more source

Landmark vector cells in the absence of visual input. [PDF]

iScience
Puliyadi V, Jayakumar RP, Johnson JL, Tran TT, Deshmukh SS, Knierim JJ.   +5 more
europepmc   +1 more source

Plastic landmark anchoring in zebrafish compass neurons. [PDF]

Nature
Tanaka R, Portugues R.
europepmc   +1 more source