Results 61 to 70 of about 581,430 (272)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Navigation Patterns and Scent Marking: Underappreciated Contributors to Hippocampal and Entorhinal Spatial Representations?

Frontiers in Behavioral Neuroscience, 2018
According to the currently prevailing theory, hippocampal formation constructs and maintains cognitive spatial maps. Most of the experimental evidence for this theory comes from the studies on navigation in laboratory rats and mice, typically male ...
Mikhail A. Lebedev, Mikhail A. Lebedev, Alexey Pimashkin, Alexei Ossadtchi   +3 more
doaj   +1 more source

Grid Cell Hexagonal Patterns Formed by Fast Self-Organized Learning within Entorhinal Cortex [PDF]

, 2009
Grid cells in the dorsal segment of the medial entorhinal cortex (dMEC) show remarkable hexagonal activity patterns, at multiple spatial scales, during spatial navigation. How these hexagonal patterns arise has excited intense interest. It has previously
Alonso, Berke, Blair, Boucheny, Burak, Burgess, Burgess, Carpenter, Carpenter, Carpenter, Carpenter, Carpenter, Egorov, Frank, Fuhs, Giocomo, Gorchetchnikov, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Hafting, Hafting, Hasselmo, Hasselmo, Hasselmo, Klink, Klink, McNaughton, Mhatre, Mhatre, Muller, O'Keefe, Olson, Redish, Rolls, Sargolini, Sharp, Skaggs, Solstad, Song, Taube, Thompson, Wilson   +45 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Anatomical organization of presubicular head-direction circuits

eLife, 2016
Neurons coding for head-direction are crucial for spatial navigation. Here we explored the cellular basis of head-direction coding in the rat dorsal presubiculum (PreS).
Patricia Preston-Ferrer, Stefano Coletta, Markus Frey, Andrea Burgalossi   +3 more
doaj   +1 more source

Function-Orientated Structural Analysis of the Proximal Human Femur [PDF]

, 2009
In his model of the biomechanics of the proximal human femur, Friedrich Pauwels assumes a resultant force acting on the femoral head that is created by the partial body weight and the force of the abductor muscles inserting at the greater trochanter ...
Baur-Melnyk, Andrea, Heimkes, Bernhard, Jansson, Volkmar, Skuban, Tobias P., Vogel, Tobias   +4 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Architectural constraints are a major factor reducing path integration accuracy in the rat head direction cell system

Frontiers in Computational Neuroscience, 2015
Head direction cells fire to signal the direction in which an animal's head is pointing. They are able to track head direction using only internally-derived information (path integration).
Hector James Ingram Page, Daniel eWalters, Simon eStringer   +2 more
doaj   +1 more source

Rheotaxis facilitates upstream navigation of mammalian sperm cells [PDF]

, 2014
A major puzzle in biology is how mammalian sperm determine and maintain the correct swimming direction during the various phases of the sexual reproduction process.
Adolphi, Bahat, Brenker, Chengala, Denissenko, Eisenbach, Elgeti, Eschenbach, Fauci, Fauci, Friedrich, Gaffney, Gibbons, Han, Ishijima, Kantsler, Katz, Kaupp, Kunz, Marcos, Marcos, Merviel, Miki, Montenegro-Johnson, Owen, Riffell, Roberts, Rothschild, Smith, Smith, Spehr, Su, Suarez, Talkner, Wilson, Winet, Woolley, Zimmer   +37 more
core   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source