Results 31 to 40 of about 397,472 (256)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Feed-forward and feedback projections of midbrain reticular formation neurons in the cat

open access: yesFrontiers in Neuroanatomy, 2014
Gaze changes involving the eyes and head are orchestrated by brainstem gaze centers found within the superior colliculus (SC), paramedian pontine reticular formation (PPRF), and medullary reticular formation (MdRF). The mesencephalic reticular formation (
Eddie ePerkins   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

The Trail Making Test in Virtual Reality (TMT-VR): The Effects of Interaction Modes and Gaming Skills on Cognitive Performance of Young Adults

open access: yesApplied Sciences
Virtual Reality (VR) is increasingly used in neuropsychological assessments due to its ability to simulate real-world environments. This study aimed to develop and evaluate the Trail Making Test in VR (TMT-VR) and investigate the effects of different ...
Evgenia Giatzoglou   +5 more
doaj   +1 more source

Sound localization with head movement: implications for 3-d audio displays.

open access: yesFrontiers in Neuroscience, 2014
Previous studies have shown that the accuracy of sound localization is improved if listeners are allowed to move their heads during signal presentation.
Ken Ian McAnally, Russell Lance Martin
doaj   +1 more source

Probing effects of lexical prosody on speech-gesture integration in prominence production by Swedish news presenters

open access: yesLaboratory Phonology, 2022
This study investigates the multimodal implementation of prosodic-phonological categories, asking whether the accentual fall and the following rise in the Swedish word accents (Accent 1, Accent 2) are varied as a function of accompanying head and eyebrow
David House, Gilbert Ambrazaitis
doaj   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Head movement is an artefact of optimal solutions to linearization paradoxes

open access: yesStellenbosch Papers in Linguistics Plus, 2014
Head movement, while endemic in natural languages, has long been a thorn in the sides of syntacticians as it does not seem to be logically necessary nor does it follow from first principles. I will argue that head movement is not only necessary – it is
de Vos, Mark
doaj   +1 more source

An “orientation sphere” visualization for examining animal head movements

open access: yesEcology and Evolution, 2020
Animal behavior is elicited, in part, in response to external conditions, but understanding how animals perceive the environment and make the decisions that bring about these behavioral responses is challenging.
Rory P. Wilson   +13 more
doaj   +1 more source

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