Results 51 to 60 of about 95,710 (303)

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

First steps: study protocol for a randomized controlled trial of the effectiveness of the Group Family Nurse Partnership (gFNP) program compared to routine care in improving outcomes for high-risk mothers and their children and preventing abuse. [PDF]

, 2013
BACKGROUND: Evidence from the USA suggests that the home-based Family Nurse Partnership program (FNP), extending from early pregnancy until infants are 24 months, can reduce the risk of child abuse and neglect throughout childhood.
Petrou, Stavros, Aistrop, D, Melhuish, E, Spiby, H, Spiby, Helen, Allen, E., Barnes, J, Elbourne, D, Pink, Joshua, Stuart, Jane, Aistrop, Dipti, Macdonald, G, Petrou, S, Joshua Pink, Diana Elbourne, Spiby, H., Barlow, Jane, Elbourne, D., Geraldine Macdonald, Barlow, J, Jane Barlow, Elizabeth Allen, Melhuish, Edward, Edward Melhuish, Allen, Elizabeth, Snowdon, Claire, Sturgess, J, Elbourne, Diana, Helen Spiby, Aistrop, D., Jane Stuart, Stuart, J, Barlow, J., Pink, J., Petrou, S., Macdonald, Geraldine, Snowdon, C, Pink, J, Stavros Petrou, Jacqueline Barnes, Macdonald, Geraldine M., Sturgess, J., Dipti Aistrop, Barnes, Jacqueline, Claire Snowdon, MacDonald, G., Snowdon, C., Melhuish, Edward C., Sturgess, Joanna, Allen, E, Joanna Sturgess   +50 more
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Situational Leadership as View by Nurses in Government and Private Hospitals

Journal of Nursing Practice, 2020
Background:Leadership as an indicator of the quality of human resources is a very determining factor in the success of an organization such as a hospital. Leadership style depends also on the maturity of individuals or groups as followers.
Diwa Agus Sudrajat, Fikri Zulfikar, Linlin Lindayani   +2 more
doaj   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

Efforts to reduce the length of stay in a low-intensity ICU: Changes in the ICU brought about by collaboration between Certified Nurse Specialists as head nurses and intensivists.

PLoS ONE, 2020
Certified Nurse Specialists (CNS) are advanced practice nurses that often play a role in management. This study aims to investigate whether cooperation between CNSs in the position of Intensive Care Unit (ICU) head nurse and intensivists change the ...
Tomohide Fukuda, Hironori Sakurai, Masanori Kashiwagi   +2 more
doaj   +1 more source

Nurse, Mary. Mary Nurse discusses nursing practices in Newfoundland

, 2001
Nurse graduated from the General Hospital School of Nursing in 1944. She worked her way to head nurse and worked in pediatrics. She talks about what it was like being one of the only, if not the only, married nurse on her level.
Walsh, Jeanette
core  

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Self-Care behaviors and their association with self-efficacy and health literacy among adolescents with type 1 diabetes mellitus in palestine: a cross-sectional study

BMC Psychology
Purpose Type 1 diabetes mellitus (T1DM) is the most common endocrine disorder during adolescence. Self-care behaviors are the cornerstone of diabetes management. Effective self-care behaviors require individuals to perform a range of complex daily tasks,
Fida Ayed, Malakeh. Z. Malak, Anas Shehadeh, Lubna Harazneh   +3 more
doaj   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source