Results 111 to 120 of about 803,099 (294)

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

A RAPID METHOD FOR THE QUANTITATIVE DETERMINATION OF ACETANILIDE IN HEADACHE POWDERS. [PDF]

, 1907
Atherton Seidell
openalex   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis

The Journal of Headache and Pain
Background Cluster headache (CH) is a highly disabling primary headache disorder with a complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available.
Zhonghua Xiong, Zhi Guo, Lei Zhao, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Geyu Liu, Tianshuang Gao, International Consortium for Cluster Headache Genetics, Yonggang Wang, Xueying Yu   +12 more
doaj   +1 more source

Do tablets cure the pedagogy headache? [PDF]

, 2016
Tablet devices have made a huge impact in schools and in 2015 they were predicted to outsell personal computers (Gartner, 2014). 70 per cent of UK schools are estimated to be using tablets (BBC, online) and across Europe, “laptops, tablets and net-books ...
Hopkins, Paul
core  

THE COMPARATIVE INCIDENCE OF POSTLUMBAR PUNCTURE HEADACHE FOLLOWING SPINAL ANESTHESIA ADMINISTERED THROUGH 20 AND 24 GAUGE NEEDLES [PDF]

, 1953
L. M. HARRIS, M. H. HARMEL
openalex   +1 more source

A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling

Advanced Science, EarlyView.
A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani, Kar Wey Yong, Mawafag F. Alhasadi, Amir Hamedzadeh, Leila Shahsavari, Atefeh Rafiei, Kalvin Wu, Omakhowa Agbojo, Anupriya Singh, Kunal Karan, Salvatore Federico, Arindom Sen, Amir Sanati‐Nezhad   +12 more
wiley   +1 more source

Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis

The Journal of Headache and Pain
Background The hypothalamus is a versatile structure comprising several nuclei that play key roles in regulating various biological processes associated with migraine, including hormone secretion, metabolism, circadian rhythm, and autonomic nervous ...
Zhonghua Xiong, Lei Zhao, Geyu Liu, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Zhi Guo, Peng Zhang, Mantian Zhang, Tianshuang Gao, Jinju Sun, Xin Liu, Yonggang Wang   +12 more
doaj   +1 more source

The Pathology of Sick-Headache [PDF]

, 1873
F. E. Anstie
openalex   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Advanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Min Zhang, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang   +12 more
wiley   +1 more source