Results 61 to 70 of about 820,695 (332)

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Headache and pregnancy. a systematic review [PDF]

, 2017
This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child during pregnancy and breastfeeding, headache ...
A. Negro, A. Terrin, B. Raffaelli, D. D. Mitsikostas, on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS), R. Ornello, S. Khan, T. A. Ivanova, U. Reuter, Z. Delaruelle   +9 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

The Impact of Biseasonal Time Changes on Migraine

Neurology International
Background: Changes in the daily rhythm can trigger migraine attacks. The sensitivity for triggering attacks is closely linked to the regulation of biological rhythms controlled by the hypothalamus.
Carl H. Göbel, Katja Heinze-Kuhn, Axel Heinze, Anna Cirkel, Hartmut Göbel   +4 more
doaj   +1 more source

Unusual Headaches [PDF]

Annals of Neurosciences, 2012
Headaches presented with unusual manner like cough, exertion, and sex, poses a diagnostic challenge in the emergency room or primary care provider's office. The majority of these patients have no underlying intracranial pathologic condition and have a good prognosis. Since the pathophysiology is poorly understood, treatment choices are limited. Further
Maheshwari, P.K., Pandey, Anjana
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Self-reported muscle pain in adolescents with migraine and tension-type headache [PDF]

, 2012
Aim: To identify possible associations between muscular pain and headache in adolescents in a large population-based sample. Methods: Grammar school students were invited to fill in a questionnaire on headache and associated lifestyle factors.
Blaschek, Astrid, Heinen, Florian, Jahn, Klaus, Kries, Rüdiger von, Langhagen, Thyra, Milde-Busch, Astrid, Reiter, Karl, Schankin, Christoph, Schröder, Sebastian Andreas, Straube, Andreas   +9 more
core   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Expert consensus on gepants for acute and preventive treatment of migraine in Thailand

The Journal of Headache and Pain
Introduction Gepants, a calcitonin gene-related peptide (CGRP) receptor antagonist, is a class of migraine therapeutic options with extensive evidence supporting a favorable efficacy and safety profile. However, as a novel class of medication in Thailand,
Prakit Anukoolwittaya, Wanakorn Rattanawong, Kiratikorn Vongvaivanich, Thanakit Pongpitakmetha, Sekh Thanprasertsuk, Thaninjitra Poonpedpun, Pannathat Soontrapa, Kanokrat Suwanlaong, Kannikar Kongbunkiat, Surasak Komonchan, Petcharat Dusitanond, Chutithep Teekaput, Nopdanai Sirimaharaj, Nadolporn Yuvasilp, Surat Tanprawate   +14 more
doaj   +1 more source

Clinical profile of SUNCT/SUNA in Japan: A clinic-based study

Cephalalgia Reports, 2019
Objectives: This study aimed to report the clinical profiles of patients with short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/short-lasting unilateral neuralgiform headache attacks with cranial ...
Shoji Kikui, Junichi Miyahara, Hanako Sugiyama, Kentaro Yamakawa, Yoshihiro Kashiwaya, Kumiko Ishizaki, Daisuke Danno, Takao Takeshima   +7 more
doaj   +1 more source