Results 121 to 130 of about 845,240 (304)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Results from tests, with van-mounted sensor, of magnetic leader cable for aircraft guidance during roll-out and turnoff [PDF]

open access: yes
Tests were conducted with a van mounted experimental magnetic leader cable sensor to evaluate its potential for measuring aircraft displacement and heading with respect to the leader cable during roll out and turnoff.
Bundick, W. T.   +2 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Levi Pennington Writing to His Niece Mary, October 2, 1946

open access: yes, 1946
Levi Pennington writing to his niece Mary about his wife\u27s health, heading the local Community Chest and overseas relief drives, and other daily life happenings.https://digitalcommons.georgefox.edu/levi_pennington/1097/thumbnail ...
Pennington, Levi T.
core  

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

A new algorithm for horizontal capture trajectories [PDF]

open access: yes
An algorithm which transfers an aircraft from an initial position and heading to a final position and heading was developed for onboard synthesis of horizontal flight paths.
Mclean, J. D.
core   +1 more source

Learning cultures on the move: where are we heading? [PDF]

open access: yes, 2010
The paper analyzes the globally recognized cultural move towards a more learner-centred education and discusses the implications for the adoption of mobile technologies and design for learning.
Kukulska-Hulme, Agnes
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Simulator evaluation of separation of display parameters in path-following tasks [PDF]

open access: yes
A five degree of freedom, fixed base simulation changing the location of the displays for bank angle, pitch angle, heading angle, and the vertical and lateral displacement from an instrument landing system path was studied.
Adams, J. J., Sarma, G. R.
core   +1 more source

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