Results 71 to 80 of about 845,240 (304)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The development of path integration: combining estimations of distance and heading [PDF]

, 2013
Efficient daily navigation is underpinned by path integration, the mechanism by which we use self-movement information to update our position in space.
A Berthoz, AD Smith, AD Smith, AE Learmonth, Alastair D. Smith, AM Hund, AW Siegel, B Plester, CC Presson, Christina J. Howard, CL Worsley, CR Gallistel, D Elliott, E Pellicano, EA Rider, EH Cornell, FN Shemyakin, GL Allen, H Mittelstaedt, I Kovas, J Bredin, JG Bremner, JJ Campos, JJ Rieser, JJ Rieser, JM Loomis, JM Loomis, JM Plumert, JM Wiener, JM Wiener, JP Corlett, JW Philbeck, L Giovannini, L Hermer, Laura McKeith, LP Acredolo, M Blades, M Müller, M Nardini, ML Mittelstaedt, ML Mittelstaedt, R Wehner, RA Ruddle, RG Golledge, RG Golledge, RL Klatzky, S Alyan, SJ Pickering, UV Saint Paul, X Wan   +49 more
core   +1 more source

Head-to-head polymers [PDF]

Journal of Polymer Science Part A: Polymer Chemistry, 2000
Head-to-head (H–H) linkages were observed in addition and condensation polymers. Pure H–H polymers of polyolefins, poly(vinyl halides), and polyacrylates were prepared, and the fundamental polymer properties were determined. They included mechanical, spectral, thermal, and degradation behaviors.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Neural Model of Motion Processing and Visual Navigation by Cortical Area MST [PDF]

, 1997
Cells in the dorsal medial superior temporal cortex (MSTd) process optic flow generated by self-motion during visually-guided navigation. A neural model shows how interactions between well-known neural mechanisms (log polar cortical magnification ...
Grossberg, Stephen, Mingolla, Ennio, Pack, Christopher   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Are We Heading Toward Socialized Medicine? [PDF]

, 2008
Defines socialized medicine, examines claims that the State Children's Health Insurance Plan and Democratic presidential candidates' reform plans would lead to government-run health care, and compares the plans with Republicans' market-oriented ...
John Holahan, Stan Dorn
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Cortical Dynamics of Navigation and Steering in Natural Scenes: Motion-Based Object Segmentation, Heading, and Obstacle Avoidance [PDF]

, 2008
Visually guided navigation through a cluttered natural scene is a challenging problem that animals and humans accomplish with ease. The ViSTARS neural model proposes how primates use motion information to segment objects and determine heading for ...
Browning, Andrew N., Grossberg, Stephen, Mingolla, Ennio   +2 more
core   +1 more source