Results 91 to 100 of about 845,240 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Distinct spatial coordinate of visual and vestibular heading signals in macaque FEFsem and MSTd

eLife, 2017
Precise heading estimate requires integration of visual optic flow and vestibular inertial motion originating from distinct spatial coordinates (eye- and head-centered, respectively).
Lihua Yang, Yong Gu
doaj   +1 more source

Application of MPC and sliding mode control to IFAC benchmark models [PDF]

, 2008
The comparison of Model Predictive Control (MPC) and Sliding Mode Control (SMC) are presented in this paper. This paper investigates the performance of each controller as the navigation system for IFAC benchmark ship models (cargo vessel and oil tanker)
Anderson, D., McGookin, E., McGookin, M.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Influence of Fatigued Core Muscles on Head Acceleration during Headers in Soccer

Sports, 2018
The core muscles play a central role in stabilizing the head during headers in soccer. The objective of this study was to examine the influence of a fatigued core musculature on the acceleration of the head during jump headers and run headers ...
Stephan Becker, Michael Fröhlich, Jens Kelm, Oliver Ludwig   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Acute Effects of Ball Pressure on Anticipation Timing Following a Series of Purposeful Headers in Adult Football (Soccer) Players

Sports
The purpose of this study is to investigate the acute effects of ball pressure on anticipation timing following a series of purposeful headers in adult football (soccer) players.
Chad McLean, Andrew P. Lavender, Ethan Pereira, Kerry Peek, Paul Davey, Fadi Ma’ayah, Susan Morris, Julia Georgieva   +7 more
doaj   +1 more source

The field high-amplitude SX Phe variable BL Cam: results from a multisite photometric campaign. II. Evidence of a binary - possibly triple - system

, 2010
Short-period high-amplitude pulsating stars of Population I ($\delta$ Sct stars) and II (SX Phe variables) exist in the lower part of the classical (Cepheid) instability strip.
A. Avdibegovic, A. Nava-Vega, A.-Y. Zhou, B. H. Granslo, B. Yasarsoy, Breger, C. Ulusoy, C. Yesilyaprak, Carney, Chandler, Claret, E. G. Hintz, E. Rodríguez, Eddington, F. Fumagalli, F. J. Aceituno, F. Van Den Abbeel, Fauvaud, Ferraro, Fu, Fu, Fu, G. Klingenberg, G. Santacana, Grether, H. Kučáková, H. Wücher, Harrington, I. Ribas, I. Scheggia, Irwin, J. A. Farrell, J. H. Simonetti, J. Kliner, J. Michelet, J.-J. Rives, J.-M. Vugnon, J.-P. Sareyan, Jeon, Jeon, K. A. Graham, K. Truparová, Kim, Kürster, L. Fox-Machado, L. Kotková, L. Král, Lenz, M. Alvarez, M. Blaĭek, M. Fauvaud, M. Helvaci, M. J. López-González, M. P. Nicholson, M. Vilášek, M. Wolf, Mathieu, Mazur, McNamara, McNamara, McNamara, O. Trondal, P. Lampens, P. Van Cauteren, P. Zasche, Perets, Preston, R. Behrend, R. Kocián, R. Michel, Ribas, Rodríguez, Rodríguez, Rodríguez, S. Bartošíková, S. Fauvaud, Sandage, Seidelmann, Szebehely, Templeton, V. M. Casanova, Zhou   +81 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source