Results 91 to 100 of about 1,678,393 (352)
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Ying-Zai Chen,1 Wei-Lieh Huang,1,2,5 Jia-Chi Shan,4,5 Yu-Hsuan Lin,1–3,5 Hung-Chieh Wu Chang,1 Li-Ren Chang1,61Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, 2Institute of Brain Science, National Yang-Ming ...
Chen YZ +5 more
doaj
Hung Manh Than,1,* Vuong Minh Nong,2,* Cap Trung Nguyen,1 Khiem Phu Dong,3 Hoa Thi Ngo,4 Tra Thu Doan,2 Nga Thu Do,2 Trang Huyen Thi Nguyen,5 Thanh Van Do,2 Co Xuan Dao,6 Tuan Quang Nguyen,6 Thach Ngoc Pham,3 Cuong Duy Do2 1Emergency Department, National
Manh Than H +12 more
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HEALTH-RELATED FAMILY QUALITY OF LIFE WHEN A CHILD OR YOUNG PERSON HAS A DISABILITY
Parents of a child or young person with disability face not only the same challenges as parents of typically developing children and young people, but also the extra challenges of supporting the child or young person with disability in such a way as to ...
Margaret R. Kyrkou
doaj +1 more source
Health-related quality of life after liver transplantation [PDF]
A Hellgren +5 more
openalex +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Marta Aymerich1, Imma Guillamón2, Albert J Jovell3,41Medical Sciences Department, University of Girona, Catalonia, Spain; 2Catalan Agency for Health Technology Assessment and Research, Barcelona, Catalonia, Spain; 3Fundació ...
Marta Aymerich +2 more
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RAD50 missense variants differentially affect the DNA damage response and mitotic progression
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Martin Strassnig,1 Jaspreet S Brar,2 Rohan Ganguli31Department of Psychiatry, Miller School of Medicine, University of Miami, Miami, FL, USA; 2Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; 3Department of Psychiatry, Centre for ...
Strassnig M, Brar JS, Ganguli R
doaj
ORAL HEALTH-RELATED QUALITY OF LIFE in CHILDREN AND ADOLESCENTS UNDERGOING ORTHODONTIC TREATMENT
Quality of Life (QoL) has an impact on the interaction and social integration of people, helping with self-confidence and well-being, which may or may not be influenced by the presence of malocclusions.
Alice Chehab +5 more
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