Results 191 to 200 of about 4,421,151 (391)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Measuring Health‐Related Quality of Life Among Patients Infected with Human Immunodeficiency Virus

, 1998
Diane Franchi, Richard P. Wenzel
openalex   +1 more source

Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer [PDF]

, 2000
John T. Wei, Rodney L. Dunn, Mark S. Litwin, Howard M. Sandler, Martin G. Sanda   +4 more
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

The impact of chronic diseases on the health-related quality of life (HRQOL) of Chinese patients in primary care [PDF]

, 2000
C. L. Lam, I Lauder
openalex   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Health-related quality of life in outpatients with COPD in daily practice: the VICE Spanish study

International Journal of COPD, 2008
Antonio Martín1, José M Rodríguez-González Moro2, José L Izquierdo3, Elena Gobartt4, Pilar de Lucas2, The VICE Study Group1Medical Department, Pfizer, Madrid, Spain; 2Service of Pneumology, HGU ...
Antonio Martín, José M Rodríguez-González Moro, José L Izquierdo, Elena Gobartt, Pilar de Lucas, The VICE Study Group   +5 more
doaj  

Health-related quality of life in total hip and total knee arthroplasty. A qualitative and systematic review of the literature.

Journal of Bone and Joint Surgery. American volume, 2004
O. Ethgen, O. Bruyère, F. Richy, Charles Dardennes, J. Reginster   +4 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Health-related quality of life in Romanian postmenopausal women with osteoporosis and fragility fractures

Clinical Interventions in Aging, 2018
Alina Deniza Ciubean,1,2 Rodica Ana Ungur,2,3 Laszlo Irsay,2,3 Viorela Mihaela Ciortea,2,3 Ileana Monica Borda,2,3 Ioan Onac,2,3 Stefan Cristian Vesa,1 Anca Dana Buzoianu1 1Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu ...
Ciubean AD, Ungur RA, Irsay L, Ciortea VM, Borda IM, Onac I, Vesa SC, Buzoianu AD   +7 more
doaj