Results 101 to 110 of about 22,351 (309)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Methodological Considerations Regarding Heterogeneity and Statistical Modeling in “Effects on Exercise Tolerance and Functional Outcomes of Eccentric versus Concentric Aerobic Exercise in People with COPD” [Letter]

International Journal of COPD
Matías Otto-Yáñez,1 Rodrigo Torres-Castro,2 Jordi Vilaró3 1Health, Functionality, and Physical Activity Research Group (GISFAF), School of Kinesiology, Faculty of Health Sciences, Autonomous University of Chile,
Otto-Yáñez M, Torres-Castro R, Vilaró J   +2 more
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

WALKING FOR HEALTH & WELLBEING: THE EFFECT OF STEP FREQUENCY

PLANNING MALAYSIA
Walking as a mode of transport and recreation to get more active and stay fit. People of all ages can benefit from walking, evaluation of earlier research in this field shows that a study of walking specifically among those with different health challenges in Malaysia is lacking.
Nurain Mohd Talmizi, Nor Eeda Haji Ali, Muhammad Rijal Mohamad, Nurhidayah Samsul Rijal, An Nisha Nur Welliana Abd Rased   +4 more
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Spotlight on Siblings: Considering Social Context in Home Modification Practice

Societies, 2019
The United Nations Convention on the Rights of Persons with Disabilities (CRPD) recognizes the role of Assistive Technologies (AT) in enabling independent living and inclusion of people with disabilities.
Jessica Moller, Alison Schneider, Emily J. Steel   +2 more
doaj   +1 more source

What evidence is there to support the impact of gardens on health outcomes? A systematic scoping review of the evidence [PDF]

, 2017
According to the World Health Organisation Global Health Observatory (2017), non-communicable diseases (NCD’s) present a significant cause of death through cardiovascular disease, respiratory conditions and type 2 diabetes.
Brettle, AJ, Hardman, M, Howarth, ML, Maden, M   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An intergenerational perspective of measuring age-friendliness across UK communities using an international measure

Cogent Gerontology
Age-friendly cities are an important initiative set out by the World Health Organization, with many researchers and policy makers aiming to create age-friendly environments to support ageing populations access and navigate the built environment.
Hannah R. Marston, Jeroen Dikken, Verina Waights, Louise M. Wallace, Joost van Hoof   +4 more
doaj   +1 more source

Book of Abstracts - Health & Wellbeing Living Lab Symposium

Book of Abstracts: Health and Wellbeing Living Lab Symposium, held on Friday, February 20, 2024, at BIP Meeting Center, Brussels, Belgium.
European Network of Living Labs, VITALISE Project   +1 more
openaire   +1 more source