Results 171 to 180 of about 13,519,843 (311)

Does the <i>AMPD1</i> C34T Polymorphism Influence Physical Performance in Elite Athletes? [PDF]

Genes (Basel)
Martin DR, Stebbings GK, Heffernan SM, Erskine RM, Antrobus M, Brazier J, Lockey S, Jackson AL, Day S, Kilduff L, Bennett M, Raleigh SM, Cullen T, Collins M, Pitsiladis Y, Callus P, Herbert AJ, Williams AG.   +17 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Digitalisation, human factors, and mental health among primary care professionals aged ≥ 50 years: a mixed-methods case study in Portugal. [PDF]

BMC Health Serv Res
Brandão MP, Chaves B.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Supporting people with type 2 diabetes mellitus through the REDE D+ social prescribing program: feasibility of a non-randomized pilot study. [PDF]

Front Public Health
Oliveira D, Henriques A, Nogueira P, Costa A.   +3 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Associations between life satisfaction and hope with cognitive function and decline over 13 years: findings from the Whitehall II study. [PDF]

Eur J Ageing
John A, Patel AMR, Desai R, Willroth E, Marchant NL, Demnitz-King H, Woodward-Carlton B, Cadar D, Bartres-Faz D, Saunders R, Bell G, Gonzalez AS, Gaysina D, Richards M, Stott J.   +14 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The exposome and the developing adolescent brain: understanding mechanisms of neuroplasticity. [PDF]

Neuropsychopharmacology
Ho TC.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source