Results 181 to 190 of about 22,531 (310)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

'It showed everyone what it was like in lockdown and how we felt': exploring short film-making with children to produce public health research dissemination. [PDF]

Eur J Public Health
Basterfield L, Batten H, Weston KL, Burn NL, Galna B, Ferguson H, Wilson S, Rimington C, Crosbie K.   +8 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Merging rigor and relevance in grazingland research: a comprehensive social-ecological monitoring approach. [PDF]

Carbon Balance Manag
Stanley PL, Kuhl AS, Maciel ICF, Cotrufo MF, Goodwin DJ, Hodbod J, Anderson MC, Scasta JD, Peirce ES, Branecky M, Brokus S, Clement RJ, DeLay ND, Derner JD, MathisonSlee M, Mitchell R, Patterson EL, Zhang Y, Asher J, Gao F, Manning DT, O'Neil G, Pallickara SL, Paustian K, Raven MR, Sacramento JP, Wu Y, Likins JM, Bista D, Colella F, Congio GFS, Dong Z, Gordon E, Gosnell H, Guber AK, Kearney SP, Lupi F, Matin A, Nimlos NM, Vivas J, Gergeni TM, Smith AP, Rowntree JE.   +42 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evaluation of early experiences of the Mental Health (Care & Treatment) (Scotland) Act 2003: A cohort study [PDF]

, 2009
Cummings, Lea, Edkins, Vincent, Fallan, Francis, Hunter, Susan, Laird, Tracy, Little, Simon, McLaughlin, Anne, Muir, Jen, Ridley, Julie, Rosengard, Ann, Thomson, Agnes, Whitelaw, Janette   +11 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

What should be included in a digital mental health intervention, based on solution-focused therapy, for young people who self-harm? A qualitative exploration of young people and clinicians' views. [PDF]

PLOS Digit Health
Jerome L, Adams K, Bird V, Ougrin D.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

RNA structure modulates Cas13 activity and enables mismatch detection. [PDF]

Nat Biotechnol
Larsen BB, Kimchi O, Dunkley ORS, Grimm MS, Siegers JY, Huang Y, Vandavasi VG, Nguyen LT, Lamb CH, Aranovich I, Eggink D, Meijer A, Jalal H, Notterman DA, Karlsson EA, Te Velthuis AJW, Myhrvold C.   +16 more
europepmc   +1 more source