Results 181 to 190 of about 22,351 (309)

'It showed everyone what it was like in lockdown and how we felt': exploring short film-making with children to produce public health research dissemination. [PDF]

Eur J Public Health
Basterfield L, Batten H, Weston KL, Burn NL, Galna B, Ferguson H, Wilson S, Rimington C, Crosbie K.   +8 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

What should be included in a digital mental health intervention, based on solution-focused therapy, for young people who self-harm? A qualitative exploration of young people and clinicians' views. [PDF]

PLOS Digit Health
Jerome L, Adams K, Bird V, Ougrin D.
europepmc   +1 more source

Evaluation of early experiences of the Mental Health (Care & Treatment) (Scotland) Act 2003: A cohort study [PDF]

, 2009
Cummings, Lea, Edkins, Vincent, Fallan, Francis, Hunter, Susan, Laird, Tracy, Little, Simon, McLaughlin, Anne, Muir, Jen, Ridley, Julie, Rosengard, Ann, Thomson, Agnes, Whitelaw, Janette   +11 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

RNA structure modulates Cas13 activity and enables mismatch detection. [PDF]

Nat Biotechnol
Larsen BB, Kimchi O, Dunkley ORS, Grimm MS, Siegers JY, Huang Y, Vandavasi VG, Nguyen LT, Lamb CH, Aranovich I, Eggink D, Meijer A, Jalal H, Notterman DA, Karlsson EA, Te Velthuis AJW, Myhrvold C.   +16 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions. [PDF]

Front Aging
Alhazzaa OA, Abahussin HM, Majrashi MA, Alotaibi MS, Alkhrayef MN, Alhamdan ZA, Alawad AO.   +6 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

COPE: C<i>ommunity</i> O<i>utreach</i> & P<i>rofessional</i> E<i>ngagement</i> - a framework to bridge public mental health services with religious organizations. [PDF]

Front Psychiatry
Milstein G, Currier JM, Dent C, McKnight M, Eckert D, Manierre A.   +5 more
europepmc   +1 more source