Results 181 to 190 of about 22,203 (309)

Fetomaternal hemorrhage: pathogenesis, diagnosis, and clinical management. [PDF]

J Perinatol
Sankaran D, Giusto E, Lim MJ, Valdez R, Lakshminrusimha S.   +4 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Cost-effectiveness of pramipexole augmentation for acute phase and maintenance therapy of treatment-resistant depression compared to placebo augmentation: economic evaluation of the PAX-D randomised controlled trial. [PDF]

Lancet Reg Health Eur
Łaszewska A, Helter T, Baldwin A, Cleare AJ, Cowen PJ, Evans J, Huys QJM, Kurkar M, Lewis AC, Nixon N, Rastogi A, Watson S, Geddes JR, Browning M, Simon J.   +14 more
europepmc   +1 more source

Evaluation of early experiences of the Mental Health (Care & Treatment) (Scotland) Act 2003: A cohort study [PDF]

, 2009
Cummings, Lea, Edkins, Vincent, Fallan, Francis, Hunter, Susan, Laird, Tracy, Little, Simon, McLaughlin, Anne, Muir, Jen, Ridley, Julie, Rosengard, Ann, Thomson, Agnes, Whitelaw, Janette   +11 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Artificial intelligence-driven exercise programmes in personalising the management of multimorbidity. [PDF]

BJGP Open
Keast J, Simpson G, Smith L, Dambha-Miller H.   +3 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Healthcare utilization data from piedmont, Italy: An administrative dataset of care episodes (2019-2024). [PDF]

Data Brief
Andrić M, Dagliati A, Dragoni M, Ricci F.   +3 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Development of the Hair & Scalp CARE questionnaire: Measuring the impact of hair and scalp issues on psychological wellbeing in healthy populations. [PDF]

Int J Cosmet Sci
Newton-Fenner A, Hirst WM, Jones T, Scott M, Roberts C, Smeets MAM, Shen J, Thomas A, Giesbrecht T.   +8 more
europepmc   +1 more source