Results 31 to 40 of about 1,023,066 (309)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Plantar Biomechanic Characteristics After High-Intensity Exercise in Young Runners With High-Arched Feet

Applied Bionics and Biomechanics
Conclusions: Our findings indicate that HI ergometer exercise has significant impacts on the biomechanic features of HA young runners. Specifically, we observed modifications in plantar area and pressure, FTI, and VGRF, especially in the medial arch and ...
Xindong Tao, Weiyi Lao, Yaoyao Zhong, Jihui Wang, Wei Ouyang   +4 more
doaj   +1 more source

Effects of different physical activity interventions on executive function in older adults with dementia: a systematic review and network meta-analysis

Frontiers in Neurology
BackgroundThe executive function impairments in older adults with dementia have profound effects on their daily lives, families, and society. Physical activity has gained recognition as a complementary treatment for enhancing executive function in ...
Ying Zhu, Shuang Li, Zixian Xiao, Hongyu Wang, Xiaolin Zhang, Qianqian Huang, Rui Yin, Kelei Guo, Dong Li   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Comparative effectiveness of open and closed skill exercises on cognitive function in young adults: a fNIRS study

Scientific Reports
While it is widely acknowledged that exercise has positive effects on cognitive function, the specific impacts of different types of exercises, particularly open and closed skill exercises, on cognitive impairment continue to be a debated topic.
Qiurong Li, Yuanpeng Zhao, Yifei Wang, Xin Yang, Qinghua He, Hejia Cai, Yongbo Wang, Hongli Wang, Yanbai Han   +8 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effects of different physical activity interventions on depressive symptoms in menopausal women: a systematic review and network meta-analysis

BMC Public Health
Background Depression in peri- and post-menopausal women burdens families and health systems. Physical activity is recognized as a complementary therapy for menopausal depressive symptoms, but prior studies lack direct comparisons of intervention types ...
Hongyu Wang, Shuang Li, Xiaolin Zhang, Ying Zhu, Qianqian Huang, Ke-Lei Guo, Dong Li   +6 more
doaj   +1 more source

Physical Education and the Preservation of Health [PDF]

The American Journal of the Medical Sciences
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openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source