Results 111 to 120 of about 2,002,821 (297)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

HIV Infection in Iran: An Update on Epidemiology, Testing and Gaps

Acta Medica Iranica
The HIV epidemic continues to disproportionately affect young and active individuals in developing and low-income countries, including Iran. Among high-risk populations in Iran, HIV prevalence peaks at 3.5% among people who inject drugs and 2.5% among ...
Seyed Ahmad Seyed Alinaghi, Mohammad Mahdi Roozbahani, Behnam Farhoudi, Seyed Ali Dehghan Manshadi, Shayesteh Jahanfar   +4 more
doaj   +1 more source

What Shapes Health-Related Behaviors? The Role of Social Factors [PDF]

, 2011
Outlines how social factors such as education, income, and neighborhood conditions affect stress levels and access to healthy choices and medical care, in turn shaping health-related behaviors.
Colleen Barclay, Paula Braveman, Susan Egerter   +2 more
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The Impact of Poor Health on Education: New Evidence Using Genetic Markers [PDF]

This paper examines the influence of health conditions on academic performance during adolescence. To account for the endogeneity of health outcomes and their interactions with risky behaviors we exploit natural variation within a set of genetic markers ...
J. Niels Rosenquist, Janet Audrain-McGovern, Steven F. Lehrer, Weili Ding   +3 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Medi-Cal Versus Employer-Based Coverage: Comparing Access to Care [PDF]

, 2015
This report takes a close look at access to care under Medi-Cal for nonelderly adults and children on the eve of Affordable Care Act (ACA) implementation. Using data from the 2012 and 2013 California Health Interview Surveys (CHIS), the research examines
A. J. Scheitler, Ninez A. Ponce, Shana Alex Charles, Tara Becker   +3 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

New England Regional Health Equity Profile & Call to Action [PDF]

, 2016
Good health is a foundation that allows people to participate in the most important aspects of life. The purpose of the New England Regional Health Equity Profile and Call to Action is to identify where differences in good health exist among racial ...
Chiu, K., Data, Research, and Evaluation Committee of the Region I Health Equity Council, Drum, Charles E., Phillips, Kimberly G.   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source