Results 51 to 60 of about 25,067,618 (293)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Hypertension and the Hmong Community: Using the Health Belief Model for Health Promotion

, 2010
Hmong Americans are a minority population with a hypertensive health problem that is often undiagnosed and not medically managed. Vulnerable populations, such as ethnic minorities, are susceptible to poor health because of their unique perception of ...
Kimberly Murphy Thalacker, Thalacker, K. M.   +1 more
core   +1 more source

O modelo das crenças de saúde (health belief model) e a teoria da autopoiesis / Health belief model and autopoesis theory

Reflexão & Ação, 2010
Este artigo tem subjacente uma intenção epistemológica, no âmbito da Educação para a Saúde (EpS). Com ele, pretendemos exemplificar como os modelos de intervenção no âmbito da EpS devem estar sustentados em paradigmas/teorias que com eles se articulam ...
Clara Costa Oliveira, Ana Feio
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Fatalism and its Effect on Health Behaviors in Mississippi and Louisiana Residents [PDF]

, 2021
The Health Belief Model maps out multiple sources to explain actions people take or do not take in regard to health behaviors. One’s sense of control over one’s own health is a central component of the health belief model. Individuals with a strong sense
Willis, Ozzie
core  

Health beliefs of women attending mammography unit and related factors

Journal of Contemporary Medicine, 2020
Aim: This descriptive study was done to evaluate the perceptions of health beliefs and related factors of women attending a mammography unit for mammograms.
Şerife Kurşun, Kamile Altuntuğ, Emel Ege, Hüseyin Özbi̇ner, Ganime Dilek Demli̇k   +4 more
doaj  

Evaluation of the relationship between health belief of breast cancer screening and health anxiety; A cross-sectional study

Medicine Science, 2019
Breast cancer (BC) is the most frequent type of cancer among women. Screening and early diagnosis is crucial for reducing the disease burden. However the screening rates for BC is not at desired levels. Health belief and health anxiety are two conditions
Meryem Askin, Esra Meltem Koc, Merve Yekta Ates, Mehmet Arslan, GizemnDag, Ali Murat Koc, Kaan Sozmen   +6 more
doaj   +1 more source