Results 141 to 150 of about 14,417,381 (310)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Provincial-level analysis of electrification feasibility and climate policy interactions

Environmental Science and Ecotechnology
Improving electrification feasibility is essential for reducing emissions from non-electric energy sources, thereby enhancing air quality and public health.
Huihuang Wu, Haozhe Yang, Xiurong Hu, Yuhan Zhou, Xian Wang, Junfeng Liu, Ying Liu, Shu Tao   +7 more
doaj   +1 more source

Benefits of Incorporating Health Promotion Courses for College Music Majors [PDF]

, 2018
Our purpose for this project was to explore correlations between music study and health and wellness. Music study involves auditory, mental, physical, and emotional health. It can also cause performance injury. In an effort to reduce performance injuries
DeBolt, Cassandra, Golubkova, Polina, Maglaya, Matthew, Vixamar, Myriam Apollon   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The mortality rate of people with cancer judged to have a limited life expectancy by physicians performing work disability assessments in the Netherlands: a retrospective cohort study

BMC Cancer
Purpose There is a lack of consensus among physicians working in the field of disability assessment about the definition of a limited life expectancy. The aim of this study was to describe the mortality rate of employees with cancer who were judged to ...
Jetske A. Kraan, Michiel A. Greidanus, Sietske J. Tamminga, Jan L. Hoving   +3 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Employment-based Health Benefits in Small and Large Private Establishments [PDF]

, 2013
[Excerpt] This issue of Beyond the Numbers compares health benefits data from private sector employers, showing variation between the smallest (those employing 1–49 workers) and the largest (those employing 500 workers or more) establishments in March ...
Wiatrowski, William J
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Health benefits of resistant starch: A review of the literature

Journal of Functional Foods, 2022
Adrianna Bojarczuk, S. Skąpska, Amin Mousavi Khaneghah, Krystian Marszałek   +3 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source