Results 161 to 170 of about 14,417,381 (310)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Do Child Tax Benefits Affect the Wellbeing of Children? Evidence from Canadian Child Benefit Expansions [PDF]
A vast literature has examined the impact of family income on the health and development outcomes of children. One channel through which increased income may operate is an improvement in a family's ability to provide food, shelter, clothing, books, and ...
Kevin Milligan, Mark Stabile
core +3 more sources
Dietary seaweed and human health [PDF]
, 2011 Seaweed as an ingredient is growing in popularity largely due to its perceived health-giving properties supported by findings from epidemiological studies.
Brownlee, Iain +3 more
core
Journal of the American Medical Association (JAMA), 2002 J. Rossouw +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Wages, Health Benefits, and Workers' Health [PDF]
, 2004 Examines the divide in the U.S. labor market between higher wage earners with health insurance, and lower wage earners who often lack coverage and access to essential health ...
Alice Ho +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
How Can Employment-Based Benefits Help the Nursing Shortage?: Executive Summary [PDF]
, 2005 Summarizes a study of the benefits available to registered nurses; trends in health insurance and retirement plan enrollment; and the role benefits play in recruitment and retention.
Joanne Spetz, Sara Adams
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source