Results 81 to 90 of about 18,655,723 (364)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Immigrants in Health Care: Keeping Americans Healthy Through Care and Innovation [PDF]

open access: yes, 2016
Immigrants play an outsized and imperative role in the U.S. health care industry. Combining existing data and profiles of immigrants across the health care spectrum, Immigrants in Health Care: Keeping Americans Healthy Through Care and Innovation ...
Marcia D. Hohn
core  

Employing a Qualitative Description Approach in Health Care Research

open access: yesGlobal Qualitative Nursing Research, 2017
A qualitative description design is particularly relevant where information is required directly from those experiencing the phenomenon under investigation and where time and resources are limited.
C. Bradshaw, Sandra Atkinson, O. Doody
semanticscholar   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Expert Consensus on Diagnosis and Treatment of NSCLC with MET Abnormalities 
(2025 Version)

open access: yesChinese Journal of Lung Cancer
The mesenchymal-epithelial transition factor (MET) gene, located on human chromosome 7, plays a crucial role in the regulation of physiological processes such as cell proliferation, migration, invasion, and angiogenesis.
Jun CHEN   +4 more
doaj   +1 more source

AGREE II: advancing guideline development, reporting and evaluation in health care

open access: yesCanadian Medical Association Journal, 2010
Clinical practice guidelines, which are systematically developed statements aimed at helping people make clinical, policy-related and system-related decisions,[1][1],[2][2] frequently vary widely in quality.[3][3],[4][4] A strategy was needed to ...
M. Brouwers   +12 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Recommendations for Senile Cataracts Evidence Base

open access: yesPhilippine Journal of Ophthalmology, 2017

Developed by Asia Pacific Center for Evidence-Based Health Care, 2016 Last Searched May 2016
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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