Results 91 to 100 of about 17,463,682 (299)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Reforming health care : a case for stay well health insurance [PDF]

All countries - whether industrial, developing, or in transition to a market economy - are interested in health care reform. A central focus of reform everywhere is to make patients more responsive to health care costs without diluting the protection ...
Bogetic, Zeljko, Heffley, Dennis
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Waivers represent a quieter way for Republicans to change health care

, 2017
How the Trump administration can use waivers to alter Medicaid and the Affordable Care Act (ACA), reforming health care at the state level. Health policy analyst Rachel Gershon delves into Section 1332 and 1115 waivers, and why they may be the next step ...
Gershon, Rachel
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Association of hemoglobin trajectories during pregnancy with preterm birth and non-reassuring fetal status: a retrospective cohort study using latent growth mixture modeling

BMC Pregnancy and Childbirth
Background Most prior studies on anemia in pregnancy, preterm birth (PTB), and non-reassuring fetal status (NRFS) use only single-trimester hemoglobin concentrations and fail to capture gestational hemoglobin changes.
Xiaohong Yu, Hongli Nie, Wenzhen Yang, Jing Tang, Xuexue Huang, Yongmei Zhao   +5 more
doaj   +1 more source

Fostering experiential learning of neurocognitive skills in brain injury tele-rehabilitation: bridging gaps in remote training by integrating scenario-based digital experiences with coaching

Frontiers in Human Neuroscience
Dysregulation of brain state is common following traumatic brain injury (TBI), contributing to long-term difficulties in important life pursuits, spanning school, work, and beyond.
Fred Loya, Deborah Binder, Nicholas Rodriguez, Bruce Buchanan, Tatjana Novakovic-Agopian, Tatjana Novakovic-Agopian, Anthony J.-W. Chen   +6 more
doaj   +1 more source

Kansas State Employees Health Care Commission Annual Report, 2014

, 2015
"Effective July 1, 2011 the administration of the State Employee Health Plan (SEHP) moved from the Kansas Health Policy Authority to the Kansas Department of Health and Environment (KDHE). The Director of the State Employee Health Benefits Program (
Kansas State Employees Health Care Commission
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Kansas State Employees Health Care Commission Annual Report, 2011

, 2012
"Effective July 1, 2011 the administration of the State Employee Health Plan (SEHP) moved from the Kansas Health Policy Authority to the Kansas Department of Health and Environment (KDHE). The Director of the State Employee Health Benefits Program (
Kansas State Employees Health Care Commission
core