Results 111 to 120 of about 1,354,273 (314)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

O apoiador institucional da Atenção Básica: a experiência em um município do interior paulista

Saúde em Debate
Trata-se de pesquisa qualitativa, realizada com sete apoiadoras institucionais de um município do interior paulista, com o objetivo de verificar o processo experiencial na gestão da Atenção Básica.
Marcella Bellini, Danielle Abdel Massih Pio, Mara Quaglio Chirelli   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Is American Health Care Uniquely Inefficient? [PDF]

The U.S. health system has been described as the most competitive, heterogeneous, inefficient, fragmented, and advanced system of care in the world. In this paper, we consider two questions: First, is the U.S.
Jonathan Skinner, Alan M. Garber
core  

Management and Administration of Health Centres [PDF]

, 1975
A study was made of the variety of administrative arrangements, the content of administrative work and the decision making processes in health centres and group practices, prior to the reorganisation of the National Health Service in April 1974 The main
Baker, Gail, Bevan, John M.
core  

Fostering experiential learning of neurocognitive skills in brain injury tele-rehabilitation: bridging gaps in remote training by integrating scenario-based digital experiences with coaching

Frontiers in Human Neuroscience
Dysregulation of brain state is common following traumatic brain injury (TBI), contributing to long-term difficulties in important life pursuits, spanning school, work, and beyond.
Fred Loya, Deborah Binder, Nicholas Rodriguez, Bruce Buchanan, Tatjana Novakovic-Agopian, Tatjana Novakovic-Agopian, Anthony J.-W. Chen   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Health and Utilization Effects of Increased Access to Publicly Provided Health Care: Evidence from the U.S. Department of Veterans Affairs [PDF]

During the mid-1990s, the U.S. Department of Veterans Affairs overhauled its health care system in an attempt to increase quality and efficiency. The restructuring involved the adoption of a capitated payment system and treatment methods based on the ...
Melissa Boyle
core  

Medicare and other federal health care program DMEPOS supplier enrollment : health care provider/supplier application. [PDF]

, 1998
"HCFA 855S.""OMB approval no.
United States. Health Care Financing Administration
core  

The VA Rural Interprofessional Faculty Development Initiative: a qualitative evaluation guided by the RE-AIM framework

BMC Medical Education
Background The Department of Veterans Affairs (VA) Rural Interprofessional Faculty Development Initiative (RIFDI) is a longitudinal, multimodal training program designed to improve the quality of and capacity for health professions education in rural ...
Sarah Keithly, Paige Perry, Erica J. Ho, Ryan A. Sterling, Soumya Subramaniam, Shaina Coogan, Sarah E. Shirley, George Sayre, Christian Helfrich, Charles Maynard, Catherine P. Kaminetzky, Erin L. Patel, Joseph Chiovaro, Joel Schmidt, Rebecca Stout, Amber Fisher, Edwin S. Wong, Megan Moldestad   +17 more
doaj   +1 more source